NORTH AMERICAN GROWTH IN CEREBRAL PALSY--PILOT DEXA PROJECT

北美脑瘫生长项目(NAGCePP)是一个多中心(4个在美国和2个在加拿大)的脑瘫生长研究中心。已确定的长期目标和研究的具体假设被划分为项目的三个阶段：第一阶段：制定议定书；第二阶段：试点/可行性研究；第三阶段：正式项目：编制增长图表。我们刚刚完成了该项目核心部分的第二阶段，并根据这一试点人类学数据向即将举行的会议提交了摘要。核心研究是以人群为基础的脑瘫儿童样本的生长发育的人体测量研究，所有中心都对此提供了数据。此外，个别中心参与了正在进行的嵌套研究，利用只有个别地点(或几个地点)贡献数据的小子样本。这些嵌套研究解决了与生长、营养状况及其对功能状况和生活质量的影响有关的更具体的问题。这项建议涉及在我们的地理区域(费城)发起的关于骨密度的嵌套试点研究。骨密度嵌套研究的具体目的如下：1.在北美两个地理区域具有代表性的、以人群为基础的脑性瘫痪儿童样本中收集有关骨密度的先导数据。2.收集基线时骨折危险因素的数据(如钙摄入量、身体大小、骨矿物质代谢指标、药物和活动水平)3.收集骨折发生率的纵向数据(通过电话随访)。4.比较脑瘫患儿和健康非脑瘫患儿股骨远端骨密度的变化。

The North American Growth in Cerebral Palsy Project (NAGCePP) was developed as a multi-center (4 sites within the United States and 2 sites in Canada) study of growth in cerebral palsy. The identified long-term goals and specific hypotheses for study were delineated into three phases of the project: Phase I: protocol development; Phase II: pilot/feasibility study and Phase III: the formal project: development of growth charts. We have just completed Phase II of the core part of this project, and have submitted abstracts to upcoming meetings based on this pilot anthropological data. The core study was an anthropometric study of growth in a population-based sample of children with CP to which all centers have contributed data. Additionally, individual centers have participated in ongoing nested studies utilizing small sub-samples to which only that individual site (or a few sites) have contributed data. These nested studies have addressed more specific questions related to growth, nutritional status, and their effects on functional status and quality of life. This proposal addresses the nested pilot study of bone mineral density that was initiated at our geographical region (Philadelphia). The specific aims of the Bone Density Nested Study were as follows: 1. To collect pilot data on bone density in a representative, population-based sample of children with CP in two geographic areas in North America. 2. To collect data on risk factors for bone fracture at baseline (e.g. calcium intake, body size, markers of bone mineral metabolism, medications and level of mobility) 3. To collect longitudinal data (by follow-up phone call) on fracture incidence. 4. To compare the results of bone mineral density at the distal femur from children with Cerebral Palsy to healthy children without Cerebral Palsy.