Microwave Treatment of Localized Prostate Cancer

描述(由申请人提供)：建议的具体目标 第二阶段的计划是设计、制造和测试狗的前列腺和 改良的局限性前列腺癌热疗治疗仪。 该仪器将使用两个配合使用的经直肠和经尿路微波 球囊导尿管将疾病的前列腺安全和均匀加热到最佳温度 治疗温度。治疗温度将通过以下方式进行监测 热电偶和数字微波辐射计。建议的高热疗法 仪器将符合所有适用的临床安全标准，并将 为后续项目的临床试验做好准备。仪器将会是 自给自足。前列腺温度将通过微处理器进行优化 它会自动确定适当的微波功率 通过每个微波球囊导管进行播送。 微波球囊导管热疗的临床应用 放射治疗[外照射或植入治疗1可预期结果 在改善局部控制和局限化患者的总体生存率方面 前列腺癌。双微波球囊热疗可提高手术质量 那些因产生尿路狭窄的患者的生活质量 在他们的尿路中放置生物支架，也应该被证明是有用的 局部复发患者姑息性治疗的单项治疗 在接受放射治疗后。 建议的商业应用： 前列腺癌影响了许多男性，总体治疗成本非常高。 建议的方法有可能提供和辅助治疗，可能 在门诊的基础上进行，以提高患者的存活率 接受外照射或种植治疗放射治疗。新型导尿管 在拟议的计划期间开发的和相关的热疗设备将 成为重要的商业产品。

DESCRIPTION (Provided by the Applicant): The specific aims of the proposed Phase II program are to design, fabricate, and test in the prostates of dogs an improved instrument for hyperthermia treatments of localized prostate cancer. The instrument will use two cooperating transrectal and transurethral microwave balloon catheters to safely and uniformly heat diseased prostates to optimum therapeutic temperatures. Treatment temperatures will be monitored by means of therrnocouples and a digital microwave radiometer. The proposed hyperthermia instrument will conform to all applicable clinical safety standards and will be ready for clinical trials in a follow-on program. The instrument will be self-contained. Prostate temperatures will be optimized by a microprocessor that automatically determines the appropriate amount of microwave power to be broadcast by each microwave balloon catheter. The addition of hyperthermia produced by microwave balloon catheters to radiation therapy [external beam or implant therapy1 can be expected to result in improved local control and overall survival rates in patients with localized prostate cancer. Dual microwave balloon hyperthermia would improve the quality of life of those patients that have constricted urethras by producing biological stents in their urethras, and should also prove useful as a stand-alone therapy for palliative treatments of patient with local recurrences after radiation therapy. PROPOSED COMMERCIAL APPLICATION: Prostatic cancer affects many men and the overall treatment costs are extremely high. The proposed approach has the potential for providing and adjuvant treatment that may be performed on an "out-patient" basis to improve the survival rates in patients being treated with external beam or implant therapy radiation. The new type of catheters developed during the proposed program and the associated hyperthermia equipment will be important commercial products.