Optical Imaging Device of the Retinal Function

描述(申请人提供)：一种视网膜光学成像设备 在第一阶段开发和测试的功能(OID-RF)将用于图像30 人类受试者。此应用程序的目标是确定 光学检测神经纤维丢失的敏感性和特异性 视网膜功能成像。OID-RE测量反射率的变化 由于氧合血红蛋白饱和度的变化而产生的视网膜 以响应活跃神经元的新陈代谢需求。建议的旧射频 利用高灵敏度电荷耦合技术的最新进展 设备(电荷耦合器件)相机和多光谱成像。OID-RF提供了一种目标， 以功能图像的形式定位信息的量化手段 整个视网膜的神经元活动。拟议中的项目将组装起来， 测试并应用一种新的商用OID-RF。同时，第一阶段的原型将 用于在爱荷华大学进行一项广泛的人体试验。 其具体目的是证明OID-RF检测NFL的敏感性。 20例因神经纤维丢失而诊断为视野丧失的患者将 进行成像并对其NFL损伤进行光学测量。 建议的商业应用：不可用

DESCRIPTION (provided by applicant): An optical imaging device of the retinal function (OID-RF) developed and tested in Phase I will be used to image 30 human subjects. The objective of this application is to determine the sensitivity and specificity for detecting nerve fiber loss through optical imaging of retinal function. OID-RE measures the change in the reflectance of the retina that occurs as a result of the changes in oxyhemoglobin saturation in response to the metabolic demands of active neurons. The proposed OlD-RF exploits recent technological advances in high sensitivity charge coupled device (CCD) cameras and multispectral imaging. OID-RF provides an objective, quantitative means of localizing information in the form of a functional image of neuronal activity across the retina. The proposed project will assemble, test, and apply a new commercial OID-RF. In parallel the Phase I prototype will be used to embark on an extensive human subject test at the University of Iowa. The specific aims are to document the sensitivity of OID-RF for detecting NFL. 20 patients with diagnosed visual field loss due to the nerve fiber loss will be imaged and their NFL damage optically measured. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE