TRAINING IN INTEGRATIVE CARDIOVASCULAR BIOLOGY

本申请是佐治亚州Me学院新设立的心血管生物学综合博士后培训助学金。该计划的长期目标是利用跨越分子、遗传、细胞组织/器官和整个动物/人范围的技术，为综合心血管生物学领域的独立基础研究事业培养博士后和医学博士研究生。这是一个跨部门和跨学科的项目，汇集了神经学、病理学、儿科、药理学、生理学、佐治亚州预防研究所、分子医学和遗传学研究所以及佐治亚州梅迪卡学院血管生物学中心的20名教职员工的专业知识。该项目的教授代表了一群杰出的心脏和血管综合生物学家，他们的研究兴趣涵盖五个相关的心血管领域：1)血管细胞信号，2)血管张力控制，3)心脏发育，4)内皮功能障碍，5)心血管疾病预防。这笔培训补助金将通过医学院血管生物学中心进行管理。该项目由项目主任约翰·D·卡特拉瓦斯博士和项目联席主任弗兰克·特雷伯博士指导，他们都是建立和调查人员。Catravas博士是血管生物学中心主任，Treiber博士是佐治亚州预防研究所主任。佐治亚医学院的一个由资深院士和领导人组成的内部咨询委员会将监督该项目。受训人员将是博士、医学博士或医学博士/博士博士后科学家。第一年需要三个博士后名额，第二-五年需要六个名额，以支持从事综合心血管生物学全日制研究的研究员。每位学员将接受2-3年的研究培训。博士后实习生将对基础综合心血管生物学有长期的职业兴趣。医学博士和医学博士/博士实习生将完成为期5年的住院医师/副专业培训。所有受训人员将被要求参加教学培训活动，包括血管生物学基础科学讲座系列、科学交流和研究伦理课程、血管生物学中心研讨会系列、期刊俱乐部、年度研究专题讨论会和博士后协会。此外，医学博士实习生将被要求参加研究统计学的研究生课程。该培训方案坚定地致力于增加接受心血管研究培训的人数不足的少数族裔和妇女的数量。研究培训设施包括血管生物学中心、佐治亚州预防研究所、分子医学和遗传学研究所的心脏开发小组、神经学、生理学和药理学系的20名教官的个人实验室和核心实验室，以及在分子生物学、组织学、转基因分析、转基因和胚胎干细胞、流式细胞术和细胞成像方面的杰出机构核心设施，总面积超过100,000平方英尺。在两个相邻的建筑和一个相邻的建筑中的研究空间。培训结束后，学员将被引导申请独立研究资金，并在高等医学院从事心血管科学的独立研究人员职业。

DESCRIPTION (Applicant's Abstract) This application is for a new post-doctoral training grant in integrative cardiovascular biology at the Me College of Georgia. The long-term objective of this program is to train post-doctoral Ph.D. and M.D. fellows for independent basic research careers in integrative cardiovascular biology, utilizing techniques spanning the molecular, genetic, cellular tissue/organ and whole animal/man range. This is an interdepartmental and interdisciplinary program incorporating the expertise of 20 faculty in the Departments of Neurology, Pathology, Pediatrics, Pharmacology, Physiology, the Georgia Prevention Institute, the Institute of Molecular Medicine and Genetics and the Vascular Biology Center at the Medica College of Georgia. The faculty preceptors of the program represent an outstanding group of integrative cardiac and vascular: biologists whose research interests cover five related cardiovascular areas: 1) vascular cell signaling, 2) control of vascular tone, 3) cardiac development, 4) endothelial dysfunction, and 5) prevention of cardiovascular disease. This training grant will be administered through-the Vascular Biology Center of the School of Medicine. The program is directed by Dr. John D. Catravas, Program Director and Dr. Frank Treiber, Program Co-Director, both establish & investigators. Dr. Catravas is the Director of the Vascular Biology Center and Dr. Treiber is the Director of the Georgia Prevention Institute. An Internal Advisory Committee of senior academicians and leaders at the Medical College of Georgia will supervise the program. Trainees will be Ph.D., M.D. or M.D./Ph.D. post-doctoral scientists. Three post-doctoral slots in the first year and six slots in years 2-5 are requested to support fellows pursuing full-time research in integrative cardiovascular biology. Each trainee will commit to 2-3 years of research training. Ph.D. post-doctoral trainees will have long term career interests in basic integrative cardiovascular biology. M.D. and M.D./Ph.D. trainees will have completed a combined 5 years of residency/sub- specialty training. All trainees will be required to participate in didactic training activities, which consist of a basic science lecture series in Vascular Biology, a course in Scientific Communications and Research Ethics, the Vascular Biology Center seminar series, a journal club, an annual research symposium and the Post-Doctoral Fellows Association. In addition, M.D. trainees will be required to take the graduate course in Research Statistics. The training program is strongly committed to increasing the number of under represented minorities and women who receive training in cardiovascular research. Facilities for research training include the individual laboratories of the 20 preceptors in, and the core laboratories of, the Vascular Biology Center, the Georgia Prevention Institute, the Heart Development Group of the Institute of Molecular Medicine and Genetics, the Departments of Neurology, Physiology and Pharmacology, as well the outstanding institutional Core Facilities in Molecular Biology, Histology, Transgenic Analysis, Transgenic and Embryonic Stem Cell, Flow Cytometry and Cell Imaging, encompassing in excess of 100,000 sq.ft. of research space in two contiguous and one adjacent buildings. Upon completion of the training program, trainees will be guided to apply for independent research funding and to pursue careers as independent investigators in cardiovascular sciences at academic medical schools.