Visceral Fat and Autonomic-Circulatory Control in Humans

描述（由申请人提供） 此K 02奖励提案要求工资支持，以保护申请人的时间 专注于拟议的研究和相关的职业发展计划。 的 首席研究员的长期职业目标是发展一个全国性的 公认的、由壁外资助的实验室致力于确定 肥胖症患者血液循环功能障碍的机制和后果， 尤其是那些腹部内脏脂肪增加的人。 为此， 本建议的目的是确定高架的影响， 腹部内脏脂肪：1）心脏迷走神经对心率的调节， 人类的肌肉交感神经活动（MSNA）; 2）动脉压力反射 刺激心脏迷走神经流出和抑制MSNA，和3）血管 对人类交感神经刺激的反应。 申请人还 建议获得有关DNA序列影响的初步数据， 单独的特定候选基因的变异以及与升高的 腹部内脏脂肪对血液循环表型的影响。 研究 在这个K 02奖提出将允许候选人扩大他的范围， 目前的R 01奖，并提高他的研究技能，在一些领域 与人类肥胖和血液循环控制有关，即，1） 扩大神经生理学和血管成像的使用和应用 技术; 2）获得身体评估的额外培训 组成和区域体脂肪分布;和3）获得经验 和生理基因组学的技能，以研究DNA序列的影响， 血管-循环表型的特定候选基因变异 单独和与升高的腹部内脏脂肪组合。 受保护 该奖项提供的时间和研究技能的提高将装备 候选人进行生物医学研究以及未来。 的结果 这项研究将提供新的生理和临床重要的 关于内脏脂肪和遗传学的贡献的信息， 结合人类在血液循环控制方面的差异。 这 考虑到越来越多的人认识到， 功能障碍可能是许多CVD状态的病因（例如，基本 高血压），所有这些都随着高血压水平的增加而变得更加普遍。 全身和腹部内脏脂肪，特别是在易感 个体 (End摘要）

DESCRIPTION (provided by applicant) This K02 Award proposal requests salary support to protect the applicants time to focus on the proposed studies and associated career development plan. The principal investigator's long-term career goal is to develop a nationally recognized, extramurally funded laboratory focused on determining the mechanisms and consequences of autonomic-circulatory dysfunction in obesity, particularly in those with elevated abdominal visceral fat. Toward this end, the aims of the present proposal are to determine the influence of elevated abdominal visceral fat on: 1) cardiac vagal modulation of heart rate and muscle sympathetic nerve activity (MSNA) in humans; 2) arterial baroreflex stimulation cardiac vagal outflow and inhibition of MSNA, and 3) vascular responsiveness to sympathetic stimulation in humans. The applicant also proposes to obtain preliminary data regarding the influence of DNA sequence variations in specific candidate genes alone and in combination with elevated abdominal visceral fat on autonomic-circulatory phenotypes. The research proposed in this K02 Award will allow the candidate to expand the scope of his current R01 award and enhance his research skills in a number -of areas related to obesity and autonomic-circulatory control in humans namely, 1) to expand the use and application of neurophysiological and vascular imaging techniques; 2) to obtain additional training in the assessment of body composition and regional body fat distribution; and 3) to obtain experience and skills in physiological genomics to study the influence of DNA sequence variations in specific candidate genes on autonomic-circulatory phenotypes alone and in combination with elevated abdominal visceral fat. The protected time and enhancement of research skills provided by this award will equip the candidate to conduct biomedical research well into the future. The results of this investigation will provide new physiologically and clinically important information regarding the contribution of visceral fat and genetics alone and in combination to human variation in autonomic-circulatory control. This information is crucial considering the growing recognition that autonomic dysfunction may be causal factor in a number of CVD states (e.g., essential hypertension) all of which become more prevalent with increasing levels of total body and abdominal visceral fat, particularly in susceptible individuals. (End of Abstract)