OPIOID INDUCED ALTERATIONS OF IMMUNE STATUS

这些目标将在三个框架内实现 美国国立卫生研究院资助的现有项目。第一个项目，名为《行为》 阿片类药物/免疫相互作用的决定因素，提供了一种检查 阿片类药物诱导的免疫状态改变，重点是 中枢神经系统和药理学变量在脑损伤中的作用 这些互动。具体来说，这项建议是进行以下方面的研究 急、慢性阿片类药物给药对免疫功能的影响 功能，并确定参与这些活动的特定大脑区域 效果。第二个项目名为免疫改变，由 条件反射，研究条件反射过程如何调节 免疫状态。这项提议涉及到审查 内源性阿片类药物在免疫功能条件性调节中的作用。 第三个项目，题为阿片类药物引起的一氧化氮改变 外周巨噬细胞产生。这个项目将决定 参与阿片诱导的阿片受体亚型(S) 一氧化氮产生的变化，并表征了 阿片类药物对体内一氧化氮产生的影响。总而言之， 这些项目将提供关于阿片类药物的重要新信息- 诱导免疫系统的调节，这个奖项将 加强这些调查。

These goals will be accomplished within the framework of three existing NIH funded projects. The first project, entitled Behavioral Determinants of Opioid/Immune Interactions, provides an examination of Opioid-induced alterations of immune status with emphasis on the role of the central nervous system and pharmacological variables in these interactions. Specifically, the proposal is to conduct studies on the effects of acute and chronic Opioid administration on immune function, and identify the specific brain regions involved in those effects. The second project entitled Immune Alterations Mediated by conditioning, examines how conditioning processes can modulate immune status. This proposal involves examining the role of endogenous opiates in conditioned modulation of immune function. The third project, entitled Opioid-induced alterations of nitric oxide production by peripheral macrophages. This project will determine the subtype(s) of Opioid receptors involved in Opioid-induced alterations of nitric oxide production, and characterize the effect of Opioid administration on nitric oxide production in vivo. Collectively, these projects will provide important new information about Opioid- induced modulation of the immune system, and this award will enhance these investigations.