ETHANOL ADMINISTRATION AND MOTOR FUNCTIONS

将进行一项研究计划，以检查乙醇对 与乙醇自身给药和感觉相关的脑区 电机集成。将以大鼠为实验模型，研究 引起行为任务排序相关的神经元活动 对乙醇自我给药的可操作性控制。的影响 感官线索的研究将在启动、维持和 终止一次饮酒“回合”。新发展的并行多神经元 将采用记录技术，该技术将长期利用组 植入微丝用于神经元棘波串检测和 统计/图形分析。将进行神经元记录 主要分布于中脑边缘系统，包括前额叶皮质 伏核的亚区及多巴胺和非多巴胺 腹侧被盖区的神经元。神经元信号将在 与类似的运动任务导致酒精的交替奖励的关系 或者是蔗糖溶液。乙醇对单音提示反应时间的影响 将对任务进行研究。这种行为的神经生理学分析 控制将为治疗的可能途径提供新的见解 对乙醇消费的监管。

A program of studies will be conducted to examine actions of ethanol on brain regions related to self-administration of ethanol and to sensory motor integration. Rats will be used as experimental models to study the activity of neurons which cause the behavioral task sequencing related to operant control of ethanol self-administration. The influence of sensory cues will be studied on the initiation maintenance and termination of a drinking 'bout'. Newly developed concurrent many-neuron recording techniques will be employed which utilize groups of chronically implanted microwires for neuron spike train detection and statistical/graphical analysis. Neuron recording will be conducted primarily in the mesolimbic system including the media prefrontal cortex subregions of the nucleus accumbens and the dopamine and nondopamine neurons of the ventral tegmental area. Neuron signals will be studied in relation to similar motor tasks leading to alternate rewards of ethanol or sucrose solution. Influence of ethanol on a tone cue reaction time task will be studied. This neurophysiological analysis of behavioral control will provide new insights into possible avenues for therapeutic regulation of ethanol consumption.