A novel cytokine-receptor survival axis in chronic myeloid leukaemia

癌细胞以不受限制的方式生长和存活。目前的治疗方法针对的是癌症的生长，但它们允许一些癌细胞长期存活，并增加了耐药和疾病复发的可能性。我们已经确定了一种新的分子开关，它在白血病中被结构性激活(不受调控)。靶向这种不受调控的细胞存活的特定成分可能为白血病治疗的治疗方法的发展提供新的和改进的方法

Cancer cells grow and survive in an unrestrained manner. Current therapies target cancer growth, however they permit the long-term survival of some cancer cells and increase the possibility of drug resistance and disease relapse. We have identified a new molecular switch that is constitutively activated (unregulated) in leukemia. Targeting specific components of this unregulated cell survival may provide new and improved approaches for the development of therapeutics in the treatment of leukemia