Quantitative SPECT for dosimetry of 131I molecular radiotherapy

放射治疗在癌症治疗中起着至关重要的作用。针对不同的器官和癌症，有不同类型的治疗方法。其中一种类型是分子放射治疗（MRT）。在这种治疗中，病人被给予一种放射性溶液，这种溶液是专门选择的，可以进入癌组织。放射性溶液释放出辐射，可以破坏组织中的癌细胞，而对周围的健康组织几乎没有损害。MRT最常见的用途是治疗甲状腺癌和放射免疫疗法，然而，它不可能提供传统放射治疗技术水平的个性化治疗计划。在治疗过程中，也不可能测量给病人的辐射剂量，这意味着对治疗影响的了解有限。这项研究的目的是开发一种成像系统，可以用来评估给病人的辐射剂量。它基于医院使用的传统放射成像技术，但专为甲状腺分子放射治疗量身定制。这项研究将导致个性化的治疗计划，这将降低治疗成本，并有可能提高癌症治疗成功率。来自利物浦大学的专家以及皇家马斯登医院和皇家利物浦大学医院的主要临床医生将进行这项研究。

Radiotherapy plays an essential role in cancer treatment. There are various types of therapy that are used to target differing organs and cancers. One such type is Molecular radiotherapy (MRT). In this treatment, patients are administered with a radioactive solution, which has been specifically chosen to travel to the cancerous tissue. The radioactive solution emits radiation, which damages the cancerous cells in the tissue, with little damage to the surrounding healthy tissue. The most common use of MRT is for treatment of thyroid cancer and radioimmunotherapy, however it is not possible to provide personalised treatment plans to the level of traditional radiotherapy techniques. It is also not possible to measure the radiation dose delivered to the patient during the treatment, which means that knowledge of the impact of the treatment is limited.This research aims to develop an imaging system that can be used to assess the radiation dose delivered to the patient. It is based on traditional radiation imaging techniques used in hospitals but is tailored specifically for molecular radiotherapy of the thyroid. The research will lead to personalised treatment planning, which will reduce treatment costs and potentially increase rates of successful cancer treatment. Experts from the University of Liverpool and leading clinicians at the Royal Marsden and Royal Liverpool University Hospitals will conduct the research.