STREPTOCOCCUS SANGUIS MICROBIAL GENOME PROJECT

描述(改编自《调查员摘要》)：调查员 链球菌基因组核苷酸序列测定的建议 桑吉斯。这一人类本土口腔微生物区系的成员长期以来 被认为是口腔细菌定植的关键因素。它 直接结合到口腔表面，并作为系绳连接到 定植于牙齿表面的各种其他口腔微生物，形成 牙菌斑，并与龋齿和牙周的病因有关 疾病。此外，血链球菌长期以来一直被认为是导致 细菌性心内膜炎是一种发病率很高的疾病，如果 未经治疗。此外，血链球菌和其他口腔绿色链球菌 在中性粒细胞减少的患者中成为威胁生命的血液病原体。 而这种感染的加剧是因为越来越频繁的 在这组微生物中观察到了青霉素耐药性。新的 关于这种微生物的知识可以用来控制口腔微生物 为了尽量减少或消除与牙菌斑有关的口腔疾病。自.以来 口腔是引起心内膜炎和肺炎的血链球菌的来源 菌血症，新的控制策略也会对全身产生影响 感染。美国血吸虫基因组数据将为这方面提供新的见解 生物体的生活方式和毒力特性不能从 分析甚至是近缘物种的基因组数据。调查人员 相信血链球菌的完整基因组结构肯定会导致 新基因的发现，对其调控的洞察，以及对 它们在基因和表型水平上的相互作用。这个，在 反过来，将为研究人员提供新的疫苗靶点，并理性地 设计的药物。

DESCRIPTION (Adapted from the Investigator's Abstract): The investigators propose to determine the nucleotide sequence of the genome of Streptococcus sanguis. This member of the human indigenous oral microflora has long been recognized as a key player in the bacterial colonization of the mouth. It directly binds to oral surfaces and serves as a tether for the attachment of a variety of other oral microorganisms which colonize the tooth surface, form dental plaque, and contribute to the etiology of both caries and periodontal disease. Furthermore, S. sanguis has been long recognized as a leading cause of bacterial endocarditis, a disease of high morbidity which is fatal if untreated. Moreover, S. sanguis and other viridans streptococci of the mouth are emerging as life-threatening bloodstream pathogens in neutropenic patients. And such infections are being compounded by the increasing frequency with which penicillin resistance is being observed in this group of organisms. New knowledge about this organism could be used in controlling oral microbial colonization so as to minimize or eliminate plaque-related oral diseases. Since the mouth is the source of S. sanguis isolates that cause endocarditis and bacteremia, novel controlling strategies also would have an impact on systemic infections. S. sanguis genomic data will provide new insights into this organism's lifestyle and virulence properties that cannot be extrapolated from analyzing the genomic data of even closely related species. The investigators believe that the complete genomic structure of S. sanguis is certain to lead to the discovery of new genes, insights into their regulation, and an appreciation of their interactions at both the genotypic and phenotypic levels. This, in turn, will provide researchers with new targets for vaccines and rationally designed drugs.