FACTOR EFFECTS ON ORAL COMPLICATIONS OF DIABETES

描述：唾液腺是几种因子的主要来源， 其在口腔和全身器官稳态中起重要作用， 伤口愈合这些因子，包括IGF-I，IGF-II， TGF-α和TGF-β以及EGF已经被充分研究。然而事实 唾液腺似乎是这些生长的主要来源 因素提出了一个有趣的问题，无论是在主要途径， 重新进入系统和这些唾液的相对重要性- 系统性地衍生蛋白质。糖尿病患者（I型和II型） 主要的疾病并发症是伤口愈合能力降低， 口腔内牙周病加重。类似的画面发生在 在糖尿病的动物模型中， 唾液中的因子与糖尿病的发病有关。因此 研究人员建议寻找唾液来源的潜在损失， 与观察到的伤口愈合减少相关的生长因子 糖尿病患者的能力。为了实现这一目标，他们首先计划 使用佛罗里达大学的糖尿病患者基础进行调查 术后患者唾液和血清中生长因子水平的变化 与健康的非糖尿病个体相比， 进行类似的程序。其次，他们打算确定 唾液中生长因子水平的变化对创伤愈合的影响 胰岛素依赖型糖尿病NOD小鼠模型。有了这个，他们打算建立NOD 小鼠作为这方面疾病的可行模型， 利用这个模型来更彻底地调查 唾液生长因子水平降低， 软硬组织损伤。这些研究的结果应该 阐明唾液源性生长因子对系统性 体内平衡和伤口修复，并可能提供深入了解 替代战略的可行性， 可能涉及创伤修复潜在缺陷的人类糖尿病 机制等

DESCRIPTION: The salivary glands are a major source of several factors, which play important roles in both oral and systemic organ homeostasis and wound healing. The roles of these factors, which include IGF-I, IGF-II, NGF, TGF alpha and beta, and EGF, has been well-studied. However, the fact that the salivary glands appear to be a major source of these growth factors present a interesting question both in the primary route of reentry into the system and the relative importance of these salivary- derived proteins systemically. In diabetic patients both (Type I and II) a major disease complication is diminished capacity of wound healing and in the oral cavity increased periodontal disease. A similar picture occurs in animal models of diabetes in there is also a progressive loss of growth factors from saliva in accordance with diabetes onset. Therefore, the investigators propose to look for the potential loss of salivary-derived growth factors associated with the observed decrease in wound healing capacity in diabetic patients. To accomplish this goal, they first plan to use the diabetic patient base of the University of Florida to investigate the changes in growth factor levels in patient saliva and serum after surgical procedures, as compared to healthy non-diabetic individuals undergoing similar procedures. Second, they intend to determine the influence of changes in growth factor levels in saliva on wound healing in the NOD mouse model for IDDM. With this, they intend to establish the NOD mouse as a viable model for this aspect of the disease and then to be able to employ this model to more thoroughly investigate the impact of decreased levels of salivary growth factors on experimentally introduced soft and hard tissue injuries. The results of these studies should elucidate the importance of salivary-derived growth factors on systemic homeostasis and wound repair and potentially provide insight into the viability of replacement strategies to combat several complications of human diabetes which may involve an underlying deficiency in wound repair mechanisms.