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NOVA RNA BINDING PROTEIN: BREAST & LUNG CANCER

NOVA RNA BINDING PROTEIN: BREAST & LUNG CANCER
NOVA RNA 结合蛋白:乳腺
批准号:
6307536
负责人:
STEPHEN K BURLEY
金额:
$0.82万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-12-01 至 2000-11-30

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中文摘要
翻译
Nova是一个高度保守的核RNA结合蛋白家族 它是皮质下运动退化相关的靶抗原 患有乳腺癌和肺癌 X射线晶体学研究 为确定各种高分辨率结构而进行的 nova-I蛋白的结构域。 MALDI-MS已用于结构域 说明,以帮助设计行为良好的结构, 结晶试验 ESI-和MALDI-MS也被用于 监测重原子掺入蛋白质构建体中 用于相位确定。
英文摘要
Nova is a family of highly conserved, nuclear RNA-binding proteins that is a target antigen in subcortical motor degeneration associated with breast and lung cancer. X-ray crystallographic studies are being undertaken to determine a high-resolution structure of the various domains of the Nova- I protein. MALDI-MS has been employed for domain elucidation to assist in designing well-behaved constructs for crystallization trials. ESI- and MALDI-MS are also being used to monitor the incorporation of heavy atoms into the protein constructs for phase determination.
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PDB MANAGEMENT BY THE RESEARCH COLLABORATORY FOR STRUCTURAL BIOINFORMATICS
  • 批准号:
    10473648
  • 项目类别:
  • 资助金额:
    $349.2万
  • 财政年份:
    2019
  • 负责人:
    STEPHEN K BURLEY
  • 依托单位:
PDB MANAGEMENT BY THE RESEARCH COLLABORATORY FOR STRUCTURAL BIOINFORMATICS
  • 批准号:
    10004836
  • 项目类别:
  • 资助金额:
    $31.13万
  • 财政年份:
    2019
  • 负责人:
    STEPHEN K BURLEY
  • 依托单位:
PDB MANAGEMENT BY THE RESEARCH COLLABORATORY FOR STRUCTURAL BIOINFORMATICS
  • 批准号:
    10476772
  • 项目类别:
  • 资助金额:
    $80.0万
  • 财政年份:
    2019
  • 负责人:
    STEPHEN K BURLEY
  • 依托单位:
PDB MANAGEMENT BY THE RESEARCH COLLABORATORY FOR STRUCTURAL BIOINFORMATICS
  • 批准号:
    10686902
  • 项目类别:
  • 资助金额:
    $349.2万
  • 财政年份:
    2019
  • 负责人:
    STEPHEN K BURLEY
  • 依托单位:
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