WASHINGTON D.C. CONSORTIUM PEDIATRIC AIDS CLINICAL TRIAL

华盛顿地区儿童艾滋病临床研究单位 （PACTU）将作为儿科艾滋病治疗小组的成员 （PACTG）与协调和运营中心（CORC）-斯佩克特。 PACTU的目标和具体目标与那些 在PACTG-CORC和RFA的科学议程中确定的。 三个主要目标是：（1）减少母婴传播 艾滋病毒传播率低于2%;（2）10年内达到90% 围产期感染艾滋病毒儿童的存活率和（3）发展 新感染婴儿早期治疗的新策略， 青少年。PACTU将进行I期、II期和III期临床试验， 研究与PACTG。PACTU拥有大量 艾滋病病毒感染者进行研究。每年有50个新的 孕妇、40名新儿童和20名新青少年 成年人了PACTU还跟踪了245名儿童和85名青少年， 年轻的成年人谁是潜在的候选人的研究。PACTU已经 四年I期、II期和II期ACTG研究经验 涉及围产期传播、初级治疗、机会性 感染、免疫治疗和长期随访。应计费用 一直高于目标，数据质量也很好。 PACTU在减少围产期死亡率的研究中特别活跃。 并已向ACTG提交概念表和胶囊 并在这一研究领域进行了补充调查。 PACTU成员担任PACTG的领导职务。的 PACTU支持CORC的科学议程，参与 制定、监测和修订科学议程; RAC和委员会的领导职位;提交胶囊 临床和基础研究的概念表; 进行RAC和委员会的研究协议;服务 进行补充调查;以及 通过会议参与成果报告， 科学出版物。

The Washington DC Regional Pediatric AIDS Clinical Research Unit (PACTU) will function as a member of the Pediatric AIDS Treatment Group (PACTG) with the Coordinating and Operations Center (CORC) --Spector. The Goals and Specific Aims of the PACTU are the same as those identified in the Scientific Agenda of the PACTG--CORC and in the RFA. The three primary goals are (1) to decrease mother-to-infant transmission of HIV to less than 2%; (2) to achieve a 90% 10 year survival for children perinatally infected with HIV and (3) to develop novel strategies for early treatment Of newly infected infants and adolescents. The PACTU will conduct Phase I, II and Ill clinical studies with the PACTG. The PACTU has available a significant number of HIV infected patients for possible study. Each year there are 50 new pregnant women, 40 new children and 20 new adolescents and young adults. The PACTU also follows 245 children and 85 adolescents and young adults who are potential candidates for studies.. The PACTU has four years of experience with Phase I, II and II, ACTG studies involving perinatal transmission, primary therapy, opportunistic infections, immune based therapy and long-term follow-up. Accrual has always been above target and the quality of data has been excellent. The PACTU is particularly active in studies to reduce perinatal transmission and has submitted concept sheets and capsules to the ACTG and has conducted supplemental investigations in this area of research. Members of the PACTU serve in leadership positions of the PACTG. The PACTU supports the Scientific Agenda of the CORC by participating in developing, monitoring and revising the Scientific Agenda; serving in leadership positions on the RACs and Committees; submitting capsules and concept sheets for clinical and more fundamental studies; conducting the research protocols of the RACs and Committees; serving on protocol teams; conducting supplemental investigations; and participating in the reporting of results through meetings and scientific publications.