BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN

描述(改编自申请人的摘要)：骨折在 儿童和儿童的骨骼健康直接受到严重威胁。 前臂远端是儿童最常见的骨折部位(1/9 儿童在儿童期和青春期前臂骨折)。近期 人们的注意力集中在增加儿童的骨密度以预防这种疾病。 几十年后的骨质疏松症。骨骼特性是否有助于 其他健康儿童的骨折风险尚不清楚。两者之间的关系 骨矿化和骨折的风险尚不清楚，因为骨矿物质含量和 密度随着年龄的增长而增加，骨折的风险也随之增加。这项研究将 检查骨量与密度和几何性质之间的关系 儿童和青少年的骨骼和前臂骨折风险 受伤。这项建议的具体目标是：(1)确定骨骼是否 密度与儿童和青少年前臂骨折风险相关 经历创伤；(2)确定骨量、密度或几何形状 测量最好地区分骨折儿童和骨折儿童 不是骨折。这些问题将通过一项病例对照研究来解决 320名5-16岁受伤的儿童和青少年 已在儿童医院医学中心接受评估，怀疑 前臂骨折。前臂骨折的骨量、骨密度和骨几何形态 病例和非骨折损伤对照将进行比较。体力活动 将对模式和饮食摄入量进行评估，以便于调查 这些因素是否以及如何与骨骼测量和骨折有关 风险。该项目将评估增加骨密度和 健康人群预防前臂骨折的骨几何学差异 儿童谁经历了伤害，并将确定最佳的骨骼测量 预测前臂骨折和这一测量的决定因素。 确定最具预测性的骨骼测量是很重要的，因此它 可作为旨在增加骨骼的干预试验的终点 儿童的质量和密度。了解这一点的决定因素 测量将为促进骨骼健康和减少 儿童时期的骨折风险。

DESCRIPTION (Adapted from the Applicant's Abstract): Fractures are common in childhood and constitute the major immediate threat to bone health in children. The distal forearm is the most common site of fracture in children (1 in 9 children sustain a forearm fracture during childhood and adolescence). Recent attention has focused on increasing bone density in children for the prevention of osteoporosis several decades later. Whether skeletal properties contribute to fracture risk in otherwise healthy children is unknown. The relation between bone mineralization and fracture risk is not clear, as bone mineral content and density increase with age along with the risk of fracture. This study will examine the relation between bone mass and density and geometric properties of bone and risk of forearm fracture in children and adolescents who experience injury. The Specific Aims of this proposal are: (1) to determine whether bone density is related to forearm fracture risk in children and adolescents who experience trauma; (2) to determine which bone mass, density or geometric measurement best discriminates between children who fracture and those who do not fracture. These questions will be addressed with a case-control study of 320 children and adolescents between 5-16 years of age that experience injury and have been evaluated at Children's Hospital Medical Center for suspicion of forearm fracture. Bone mass, density and bone geometry of forearm fracture cases and non-fractured injured controls will be compared. Physical activity patterns and dietary intake will be assessed to allow investigation as to whether and how these factors are related to bone measurements and fracture risk. This project will evaluate the importance of increased bone density and differences in bone geometry for preventing forearm fractures in healthy children who experience injury, and will identify the best bone measurement for predicting forearm fractures and the determinants of this measurement. Identification of the most predictive bone measurement is important so that it can be used as an endpoint in intervention trials designed to increase bone mass and density in children. Understanding the determinants of this measurement will inform strategies to promote healthy bone and decrease fracture risk in childhood.