CORE--MOLECULAR GENETICS

我们的假设是某些基因座上的分子变异会影响血液 压力调节使个体更容易发生 原发性高血压。多因素决定和异质性 这表明有几个基因可能在其中起主导作用 遗传成分。在这个H-SCOR中，我们将检查选定的基因 在盐/容量敏感型高血压患者中 项目1和2.遗传连锁分析，直接搜索 突变和选定基因座的基因分型可能有助于识别 在这两个项目中进行生理学研究的‘遗传学’亚组。这 CORE还将协助项目3-5中的调查人员开发标记 或其他分子遗传学方法，如有需要。

Our hypothesis is that molecular variants at some loci affecting blood pressure regulation predispose individuals to the development of essential hypertension. Multifactorial determination and heterogeneity suggest that several genes may account for a predominant fraction of this genetic component. In this H-SCOR, we will be examining selected genes in patients with salt/volume sensitive hypertension as outlined in Projects 1 and 2. Analysis of genetic linkage, direct search for mutations, and genotyping at select loci may help in identifying 'genetic' subgroups for physiological studies in these two projects. This core will also assist investigators in projects 3-5 in marker development or other molecular genetic approaches as the need arise.