Integration of transplanted ESNLCs into spinal circuits

描述：(摘要用途)项目IV将研究将移植的ESNLC整合到受损的脊髓回路中。通过使用传统的生理和解剖学工具，ESNLC移植所产生的恢复将在具有良好特征的脊髓回路中进行评估。具体地说，肌向性反射的恢复将与球脊髓的恢复相关，移植诱导的球脊髓、本体脊髓和肌肉传入投射到脊髓的恢复的底物。对于移植诱导功能恢复的电路底物也将进行评估，即细胞凋亡。该项目将依赖于动物损伤/动物核心C，与其他项目和核心密切合作，将康复的生理和解剖基础与最佳ESNLC治疗策略的行为效果联系起来。

Description: (Abstract use) Project IV will study the integration of transplanted ESNLCs into injured spinal circuits. By the use of conventional physiological and anatomical tools, recovery produced by ESNLC transplants will be assessed in well-characterized spinal circuits. Specifically, the recovery myotactic reflex will be correlated with the recovery of bulbospinal, substrates for transplant induced recovery of bulbospinal, propriospinal and muscle afferent projections to the spinal cord. The circuit substrates for transplant-induced recovery of function will also be evaluated, apoptosis. The project will rely on the Injury/Animal CORE C for animal closely work with the other Projects and Cores to relate physiological and anatomical substrates of recovery with the behavioral effects of an optimal ESNLC treatment strategy.