RES FACIL CONSTRUCTION: HALLUCINOGENS

描述（由申请人提供）：NYSBC是一个由九个学术医学研究机构组成的财团，提议建造一个10，000平方米的英尺除了现有的设施，以容纳三个国家的最先进的冷冻EM。其目的是扩大NYSBC的科学范围，目前主要集中在磁共振光谱学，通过创建一个资源和程序在补充领域的低温EM。这些新资源将服务于一个大型的、国际公认的、由美国国立卫生研究院（NIH）资助的生物学家社区，这些生物学家目前还没有足够的（或任何）机构获得冷冻EM。拟议的扩展将为超过25个直接使用cryo EM或与晶体学和磁共振光谱学结合使用的研究小组提供服务，以研究蛋白质和超分子机器。另外40名目前没有使用低温EM的研究人员将能够在他们的领域中进行更困难的问题，并获得扩展后的NYSBC提供的综合资源。NYSBC位于纽约城市学院（CCNY）的校园内，位于上曼哈顿的第133街和修道院大道。它分三个阶段建造：1）第一和第二阶段将安装一组高场磁共振光谱仪（750、800和900兆赫）;第一阶段将于2002年3月31日投入使用;第二阶段将于2002年12月31日投入使用。本申请仅用于第三阶段的资助。它包括10，000平方米。英尺容纳120 kV、200 kV和300 kV的三个低温EM以及必要的辅助活动。

DESCRIPTION (provided by applicant): The NYSBC, a consortium of nine academic medical research institutions, proposes to construct a 10,000 sq. ft. addition to its existing facilities to house three state-of-the-art cryo EM. The objective is to expand the NYSBC's scientific scope, which currently focuses on magnetic resonance spectroscopy, by creating a resource and program in the complementary field of cryo EM. These new resources will serve a large, internationally-recognized community of National Institutes of Health (NIH)-funded biologists who do not currently have adequate (or any) institutional access to cryo EM. The proposed expansion will serve more than 25 research groups that use cryo EM directly, or in conjunction with crystallography and magnetic resonance spectroscopy, to study proteins and supramolecular machines. Another 40 researchers who do not currently use cryo EM, will be able to undertake more difficult problems in their fields with access to the integrated resources provided by the expanded NYSBC. The NYSBC is located on the campus of City College of New York (CCNY) at 133rd Street and Convent Avenue in Upper Manhattan. It is being constructed in three phases: 1) Phases I and II will house a group of high-field magnetic resonance spectrometers (750, 800 and 900 at MHz); Phase I will be operational by March 31, 2002; and Phase II will be operational by December 31, 2002. This application is for Phase III funding only. It comprises 10,000 sq. ft. to house three cryo EM at 120 kV, 200 kV, and 300 kV, and necessary ancillary activities.