TREATMENT FOR ALCHOLISM: A PRIMATE MODEL

本提案旨在研究酒精中毒的治疗方法以及这些治疗方法可能最有效的条件。实验包括检查两种药物治疗的有效性，纳曲酮，一种阿片拮抗剂和布雷马辛，一种阿片受体激动剂，在减少恒河猴口服乙醇的自我管理。此外，某些变量可能会影响治疗药物的有效性。因此，将研究开放与封闭经济对布雷马辛效果的影响。在一个开放的经济中，除了获得的乙醇外，还允许补充乙醇的数量，而在一个封闭的经济中，主体可以获得全部的乙醇。这种模式允许研究治疗药物的选择性。此外，重要的是要了解乙醇维持的行为如何因性别而异。因此，布雷马嗪和纳曲酮对乙醇自我给药的影响将作为性别的函数进行研究。

DESCRIPTION This proposal was designed to allow for the investigation of treatments for alcoholism and the conditions under which these treatments may prove most effective. The experiments consist of examining the effectiveness of two pharmacological treatments, naltrexone, an opioid antagonist and bremazocine, a kappa opioid agonist, in reducing self- administration of oral ethanol by rhesus monkeys. Furthermore, it is possible that certain variables may influence may influence the effectiveness of treatment drugs. Therefore, the influence of an open versus closed economy on the effects of bremazocine will be investigated. An open economy allows for supplemented amounts of ethanol in addition to that which is earned, and in a closed economy the subject earns the entire amount. This paradigm allows for the investigation of the selectivity of treatment drugs. In addition, it is important to understand how ethanol-maintained behavior may differ as a function of sex. Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated.