METFORMIN IN OBESE ADOLESCENTS PREDISPOSED TO TYPE II DIABETES

患有胰岛素抵抗的肥胖青少年在成年后易患II型糖尿病。这项研究考察了二甲双胍对空腹胰岛素水平升高的肥胖青少年和患有II型糖尿病的一级亲属的胰岛素敏感性的影响。这项试验是双盲的，安慰剂对照。在这项研究中，肥胖青少年接受了快速静脉葡萄糖耐量测试，允许使用Bergman最小模型进行胰岛素敏感性的基线评估。然后，患者被分配到药物组或安慰剂组，总共六个月，监测空腹血糖、胰岛素、糖化血红蛋白、血脂和体重、血压和全身脂肪。在试验结束时，通过重复静脉葡萄糖耐量试验来评估胰岛素敏感性。患者登记和所有测试现已完成。我们目前正处于分析数据的初始阶段。这些研究结果可能为预防易患糖尿病的患者提供一种新的方法。

Obese adolescents with insulin resistance are predisposed to the development of Type II diabetes mellitus in adulthood . This study examines the effects of Metformin on insulin sensitivity in obese adolescents with elevated fasting insulin levels and first degree relatives with Type II diabetes. The trial is double-blind and placebo controlled. In the study, obese adolescents undergo a rapid intravenous glucose tolerance test, permitting baseline assessment of insulin sensitivity using the Bergman minimal model. Patients are then assigned to drug or placebo groups for a total of six months, with monitoring of fasting plasma glucose, insulin, glycosylated hemoglobin, plasma lipids and weight, blood pressure and total body fat. Insulin sensitivity is assessed at the end of the trial by repeating the intravenous glucose tolerance test. Enrollment of patients and all testing have now been completed. We are currently in the initial phases on analyzing the data. The results of these studies may provide a new approach to the prevention of diabetes mellitus in patients predisposed to the disease.