CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS

描述(摘自摘要)：HIV-1病毒复制的控制 感染和感染后的疾病与感染的程度相关 CD8+T淋巴细胞反应。CD8+淋巴细胞的中枢作用 介导的细胞免疫反应在控制病毒复制中的作用 直接使用猕猴免疫缺陷病毒进行了验证 (SIVmac)/恒河猴艾滋病模型。然而，一个更详细的描述 CD8+淋巴细胞介导的解剖分布和功能 对于制定预防或治疗艾滋病毒-1感染的战略至关重要。在……里面 特别是控制病毒复制的机制，即 这些病毒特异性CD8+淋巴细胞在不同人群中的解剖分布 淋巴组织及其在艾滋病中的潜在作用 发病机制尚不完全清楚。 这是一个修改后的应用程序，建议探索解剖分布 SIV特异性CTL的表达及CD8+淋巴细胞在免疫发病中的作用 CD4+T细胞在艾滋病病毒感染中的下降。具体来说， 1.描述SIVmac特异性CD8+T淋巴细胞在体内的解剖分布 原发感染和 2.测定CD8+T细胞在CD4+T细胞丢失中的作用 感染SIVmac或快速CD4+T细胞耗尽病毒后 Shiv-KB9。

DESCRIPTION (from abstract): The control of virus replication in primary HIV-1 infection and disease following infection are correlated with the magnitude of the CD8+ T lymphocyte response. The central role of this CD8+ lymphocyte mediated cellular immune response in controlling virus replication has recently been demonstrated directly using the simian immunodeficiency virus of macaques (SIVmac)/rhesus monkey model of AIDS. However, a more detailed characterization of the anatomic distribution and functions mediated by CD8+ lymphocytes is essential for developing strategies to prevent or treat HIV-1 infection. In particular, the mechanism by which virus replication is controlled, the anatomic distribution of these virus-specific CD8+ lymphocytes among various lymphoid tissues and the potential contribution of these cells to AIDS pathogenesis are not fully understood. This is an amended application proposing to explore the anatomic distribution of SIV-specific CTL and the role of CD8+lymphocytes in the immunopathogenesis of CD4+T cell decline in AIDS virus infection. Specifically, 1. Describe the anatomic distribution of SIVmac-specific CD8+ T lymphocytes in primary infection and 2. Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9.