LATE EFFECTS IN SURVIVORS OF STEM CELL TRANSPLANTATION

描述：(申请人描述)K.Scott Baker医学博士是一名儿科医生 加州大学血液和骨髓移植专业肿瘤学家 ，并被任命为明尼苏达州的助理教授 儿科。应聘者的职业目标是：1)发展 具有扎实临床研究基础的临床研究专业知识 方法、流行病学和生物统计学，2)将这些活动的重点放在 面向患者的造血干细胞领域研究 移植(SCT)，特别是移植相关的并发症和晚期 效果，3)利用这些新获得的技能来实现 作为独立临床调查员的地位。计划中的职业 发展计划将提供全面的、多学科的、紧密的 有指导，以病人为导向的研究经验。这将在#年完成 与临床研究中的正规教学培训相结合 在美国攻读临床研究硕士学位 流行病学系。在莱斯利·罗宾逊博士和 诺玛·拉姆齐博士，候选人将启动对已故 SCT后长期存活者的效果。拟议的研究将 建立SCT的前瞻性、前瞻性和长期随访研究 明尼苏达大学的幸存者为系统的，礼仪驱动的， 评估本病的发生率、危险因素和特点。 心肺、肾、内分泌和生殖后遗症的质量 生活结局和第二种恶性肿瘤。假设驱动 还将对目前1226人进行调查 长期的幸存者。这些研究将包括对不同 移植调理方案(全身照射、全淋巴系 放疗和仅限化疗)对儿童随后的晚期反应，以及 与治疗相关的后遗症的谱系和严重程度分析 在第二个十年的长期跟踪中发展，并分析了 慢性移植物抗宿主病对远期疗效和质量的影响 在SCT幸存者中的生活。候选人还将利用来自 正在进行的多机构儿童癌症存活者研究(Robison博士是 首席调查员)对该队列中的患者进行比较分析 接受标准化疗的患者与接受SCT的患者 他们的治疗。

DESCRIPTION: (Applicant's Description) K. Scott Baker, M.D. is a pediatric oncologist in the Blood and Marrow Transplant Program at the University of Minnesota, and holds an appointment as an Assistant Professor in the Department of Pediatrics. The candidates career goals are: 1) to develop clinical research expertise which has a solid foundation in clinical research methodology, epidemiology, and biostatistics, 2) to focus these activities on patient oriented research in the field of hematopoietic stem cell transplantation (SCT), specifically transplant related complications and late effects, 3) to utilize these newly acquired skills in order to achieve the status as an independent clinical investigator. The proposed career development plan will provide a comprehensive, multidisciplinary, closely mentored, patient oriented research experience. This will be accomplished in conjunction with formal didactic training in Clinical Research obtained by the candidate enrolling in the master's degree program in clinical research in the Division of Epidemiology. Under the mentorship of Dr. Leslie Robison and Dr. Norma Ramsay, the candidate will initiate investigations into the late effects seen in long-term survivors after SCT. The proposed research will establish prospective and retrospective, long-term follow-up studies of SCT survivors at the University of Minnesota for the systematic, protocol driven, evaluation of the incidence, risk factors, and characteristics of cardiopulmonary, renal, endocrine and reproductive late effects, quality of life outcomes, and second malignant neoplasms. Hypothesis driven investigations will also be undertaken in the current population of 1226 long-term survivors. These will include studies of the impact of different transplant conditioning regimens (total body irradiation, total lymphoid irradiation, and chemotherapy only) on subsequent late effects in children, an analysis of the spectrum and severity of treatment related sequelae which develop in the second decade of long-term follow-up, and an analysis of the impact that chronic graft-versus-host disease has on late effects and quality of life in SCT survivors. The candidate will also utilize data frorn the ongoing, multi-institutional, Childhood Cancer Survivor Study (Dr. Robison is Principal Investigator) for a comparative analysis of patients in that cohort receiving standard chemotherapy versus those who have undergone SCT as part of their therapy.