ZUNI KIDNEY PROJECT - FAMILY STUDIES

祖尼普韦布洛位于新墨西哥州，人口11500人。 这一小部分与世隔绝的人口几百年来一直保持着相对的同族通婚。 祖尼的终末期肾病患病率分别是美国白色和美国印第安人复合患病率的11倍和4倍。非胰岛素依赖型糖尿病在祖尼人中的流行率很高，这一流行病主要是由于糖尿病肾病。 祖尼的几乎每个人都有ESRD的亲戚，这导致了社区对肾脏研究的强烈支持。 为了满足这一需求，我们建立了祖尼肾脏项目，该项目正在对所有大于或等于5岁的祖尼居民进行基于人口的调查。 我们正在确定所有参与者的家庭结构和量化血糖控制，蛋白尿和肾功能。本项目将建立一个DNA储存库，并确定基因组片段和环境-遗传相互作用，调节糖尿病肾病和中间表型的发病和/或进展的风险。 我们的调查小组包括来自祖尼普韦布洛、新墨西哥州大学健康科学中心、印度卫生服务、西南生物医学研究基金会、NIDDK凤凰城办事处、宾夕法尼亚大学强心研究和Istituto Scientific H San Raffaele的代表。 这种协作方法使我们能够直接比较在祖尼与皮马印第安人和强心研究参与者中获得的结果。 这些美洲原住民人群中获得的结果将与其余参与研究中心研究的其他种族群体中的结果进行比较。

The Zuni Pueblo, located in New Mexico, has a population of 11,500. This small, isolated population has been relatively endogamous for several hundred years. The prevalence of end-stage renal disease at Zuni is 11- and 4- fold higher the U.S. White and composite American Indian rates, respectively. The prevalence of non-insulin-dependent diabetes mellitus is high among the Zuni and the epidemic is attributable mainly to diabetic nephropathy. Almost everyone at Zuni has a relative with ESRD, leading to strong community support for renal research. In response to this need we established the Zuni Kidney Project which is conducting a population-based survey of all Zuni residents greater than or equal to 5 years of age. We are ascertaining family structure and quantifying glycemic control, proteinuria, and renal function in all participants. The present project will establish a DNA repository and identify genome segments and environmental-genetic interactions that modulate the risk for the onset and/or progression of diabetic nephropathy and intermediate phenotypes. Our investigative team includes representatives from the Zuni Pueblo, University of New Mexico Health Sciences Center, Indian Health Service, Southwest Foundation for Biomedical Research, Phoenix office of NIDDK, Strong Heart Study, University of Pennsylvania, and the Istituto Scientifico H San Raffaele. This collaborative approach allows us to directly compare results obtained in the Zuni with those in Pima Indians and Strong Heart Study participants. Results obtained in these Native American populations will be compared with those in other ethnic groups studied by the remaining participating investigating centers.