Dysferlin and the emergency vesicle fusion of membrane repair

膜修复是所有真核细胞的一种重要的细胞生存机制，它利用钙离子触发的囊泡融合来修补膜破裂。肌营养不良蛋白deferlin是膜修复的关键介体，尽管目前还不清楚deferlin究竟如何修复膜。我们发现，通过膜撕裂而来的钙，激活了一组称为钙调蛋白的酶，这种酶专门裂解去铁蛋白，释放专门的囊泡融合模块进行膜修复。

Membrane repair is a vital cell survival mechanism of all eukaryotic cells, using calcium-triggered vesicle fusion to ‘patch’ membrane ruptures. The muscular dystrophy protein dysferlin is a key mediator of membrane repair, although, exactly how dysferlin mends membranes has been unclear. We show that the calcium that floods through membrane tears, activates a group of enzymes called calpains, that specifically cleave dysferlin to release a specialist vesicle-fusion module for membrane repair.