Investigation of a regulatory iron-sulfur complex in a bacterial sigma factor

泰国伯克霍尔德菌产生马来杆菌蛋白，用来捕获铁。编码malleobactin生物合成的基因受sigma因子mba控制，并在铁限制条件下表达。mba的特征表明它在c端具有铁感应结构域。我们假设在铁充足的条件下，mba获得铁硫簇，抑制mba - rna聚合酶与启动子DNA的关联。

The bacterium Burkholderia thailandensis produces malleobactin which it uses to capture iron. The genes encoding the biosynthesis of malleobactin are under the control of the sigma factor MbaS and are expressed under iron limiting conditions. The characteristics of MbaS suggest that it possesses an iron-sensing domain at its C-terminus. We hypothesise that under iron sufficient conditions, MbaS acquires an iron-sulfur cluster which inhibits association of MbaS-RNA polymerase with promoter DNA.