DEFECTS OF ACTION SPACE IN PARKINSONS DISEASE (PD)

描述：(逐字摘自申请者的摘要)空间忽视损害了 人与环境互动的能力。的许多症状 单侧大脑半球注射神经毒素可导致忽视 单方面损害多巴胺能系统。然而，在标准测试中， 大多数帕金森氏病(PD)患者不会表现出忽视。 帕金森病患者最常见的是双侧多巴胺功能障碍和 发现这些患者的单侧忽视可能与双侧的 这种病。已经有几个关于双侧卵巢癌患者的报道。 忽略近距离或远距离周围空间的病变。以了解患者是否 由于帕金森病可能忽略了远距离的个人空间，我们进行了一项初步研究。 在这项研究中，我们试图了解感知到的线的大小或幅度 运动能力受刺激的空间位置的影响 对身体来说。我们发现，当帕金森病受试者感觉到身体附近的线条时 (中间)和疲倦的横向移动等距离，他们是过速。 然而，当他们看到一条侧线，并向中央(内侧)移动时 他们都是强直性的。这些结果提示帕金森病患者可能 要么对空间有异常的感知，要么有异常的反应模式 两者都有。这个项目的目的是进一步研究帕金森氏症患者 空间知觉和运动动作所以不知道距离周围的空间是不是 与个人周围空间不同的表现形式

DESCRIPTION: (Verbatim from the Applicant's Abstract) Spatial neglect impairs a person's ability to interact with their environment. Many of the symptoms of neglect can be induced by unilateral hemispheric injections of neurotoxins that unilaterally impair the dopaminergic systems. However, on standard test of neglect most patients with Parkinson's disease (PD) do not demonstrate neglect. PD patients most often have bilateral dopamine dysfunction and the failure to find unilateral neglect in these patients may be related to the bilaterality of this disease. There have been several reports of patients with bilateral lesions who had neglect of near or far peripersonal space. To learn if patients with PD may be neglecting far peripersonal space, we performed a pilot study. In this study we attempted to learn if the perceived size of lines or amplitude of movements were influenced by the spatial location of the stimulus in respect to the body. We found that when PD subjects perceived lines close to their body (medial) and tired to move an equal distance laterally they were hypometric. However, when they prceived a line laterally and movements centrally (medial) they were hypometric. These results suggested to us that patietns with PD may have either an abnormal perception of space, an abnormal response pattern or both. The purpose of this program is to further study Parkinson's patients spatial perceptions ad motor action sot learn if far peripersonal space is represented differently than near peripersonal space