STAGES OF MOTOR SKILL CONSOLIDATION IN THE HUMAN BRAIN

我们的目的是研究电动机输出功率的变化 当人类学习一个运动时， 手臂的技巧，并描述如何神经和功能 在完成后的几个小时内技能变化的表示 实践我们假设在这几个小时里，运动记忆经历了 巩固的过程。我们的主要实验工具是一个机器人 受试者学会用手臂控制系统。我们将执行 心理物理学和神经成像实验， 建模追求以下目标：理解，使用 数学模型，在电机输出中发生的变化， 到达运动是在一个新的力场;描述时间 运动记忆功能特性的变化过程 完成练习后;描述运动的神经相关性 通过功能成像巩固记忆;询问时间是否- 与运动记忆相关的依赖性功能特性在 健忘症;为了更好地了解小脑和纹状体的作用 通过研究患者的运动学习， 患有小脑疾病和亨廷顿氏病以更好的 了解正常的大脑如何学习新的运动技能，以及 时间会影响它的表现，我们会更好地了解电机 受损大脑的学习和康复过程。

We aim to study the changes that take place in the output of the motor system and its neural correlates in the brain as humans learn a motor skill with the arm, and describe how the neural and functional representation of the skill changes in the hours after completion of practice. We hypothesize that during these hours, motor memories undergo a process of consolidation. Our principal experimental tool is a robotic system that subjects learn to control with their arm. We will perform psychophysical and neuroimaging experiments coupled with computational modeling to pursue the following objectives: To understand, using a mathematical model, the changes that take place in the motor output as reaching movements are made in a novel force field; To describe the time course of changes in functional properties of motor memory in the hours after completion of practice; To describe the neural correlates of motor memory consolidation through functional imaging; To ask whether the time- dependent functional properties associated with motor memory are intact in amnesia; To better understand the role of the cerebellum and the striatum in learning of reaching movements by studying motor learning in patients with cerebellar disease and Huntington's Disease. With a better understanding of how the normal brain learns a new motor skills and how time influences its representation, we will better understand motor learning and rehabilitation processes in the damaged brain.