MOVEMENT ORGANIZATION DYSFUNCTION IN PARKINSONS

虽然近年来帕金森氏病的研究取得了进展，但这种疾病的发病机制仍未得到很好的理解。该项目的主要目标是量化帕金森病患者复杂的多关节运动受损程度，从而更好地了解运动控制原理是如何受损的。我们对PD患者的工作假设是，他们复杂运动的困难大多源于他们无法协调身体各部分。我们使用躯干辅助抓取任务，并分析了当速度、精度、片段排序和视觉反馈约束施加时躯干、手臂和孔径同步。我们将分析身体片段同步、相对定时、空间不变性和协同作用。总的来说，这些实验的结果将使我们更好地了解PD在复杂动作的表现中如何影响运动协调模式。off和off的比较。帕金森病患者的“开”状态可能有助于确定协调障碍是否与左旋多巴有共同的基础。所提出的实验是系统的，新颖的，并使用行之有效的方法。拟议的研究应促进对指导正常受试者多关节运动协调的基本原则的理解。它还将增加对帕金森病患者在使用这些原则时受到限制的方式的理解。四个实验的结果应该对基础神经科学家和临床科学界都有用，减少神经机制的基础知识和治疗干预之间的差距。

While advances in Parkinson's disease have been established in recent years, the pathogenesis of the disease is still not well understood. The primary goal of this project is to quantify how complex multijoint movement is impaired in Parkinsonian patients, thereby providing a better understanding of how motor control principles are compromised. Our working hypothesis concerning PD patients is that much of their difficulty with complex movements arises from their inability to coordinate body segments. We use a trunk-assisted prehension task and analyze trunk, arm, and aperture synchronization when speed, accuracy, sequencing of segments, and visual feedback constraints are imposed. We will analyze body segment synchronization, relative timing, spatial invariance, and synergies. Collectively, the results from these experiments will allow us to better understand how PD affects movement coordination patterns during the performance of complex actions. Comparisons of 'off' vs. 'on' states in Parkinson's disease patients may help determine if coordination impairments share a common levodopa basis. The experiments proposed are systematic, novel and use proven methodology. The proposed research should advance understanding of the fundamental principles that guide the coordination of multijoint movements in normal subjects. It will also increase understanding of the ways in which Parkinson's disease patients are restricted in the use of these principles. The results from four experiments should be useful to both the basic neuroscientist and clinical science communities, reducing the gap between fundamental knowledge of neural mechanisms and therapeutic intervention.