Conference On Aminoacyl tRNA Synthetases

说明（申请人提供）氨酰-tRNA合成酶是关键酶 在蛋白质合成中起着重要作用， 通过其同源物的氨酰化将氨基酸转化为特定的三核苷酸 tRNA。因此，它们的结构/功能关系提供了重要的 对早期解码系统的深入了解。本申请 描述了一个拟议的研讨会，题为"生物学中的氨酰-tRNA合成酶， 医学与进化"将在加州的阿西洛马会议上举行， 2001年9月23日至28日。由于进展迅速， 合成酶领域的跨学科性质，本次研讨会的组织 是必要的.会议的形式将遵循戈登研究 会议时间表，2004年共举行九次正式科学会议， 早上和晚上。海报会议和非正式科学讨论 将在下午举行。在每一次会议上， 高级调查员将提供大约30分钟的时间， 另外两到三个简短的演讲也将由选定的发言者提出 根据提交的摘要。九届会议将重点讨论核心问题 tRNA合成酶的结构和功能问题，以及其他 新兴利益的话题。这些机制包括特异性和 编辑，识别tRNA和tRNA样分子， 合成酶和人工氨酰化系统。这次阿西洛马会议 这是一个独特的机会，可以将两位高级调查员聚集在一起， 该领域和年轻的科学家谁仍在建立自己的职业生涯。 参与者将从一个高度互动的科学家小组中选出， 各种学科，包括来自美国， 欧洲和日本。这是去年举行的第四次此类会议 前几次会议分别在法国奥特朗（1990年）、新墨西哥州陶斯举行 （1997），Mittelwihr，France（1998）。

DESCRIPTION (provided by applicant) Aminoacyl-tRNA synthetases are key enzymes in protein synthesis and act as interpreters of the genetic code by relating amino acids to specific tri-nucleotides through aminoacylation of their cognate tRNAs. As such, their structure/function relationships provide important insights into early systems of the decoding machinery. This application describes a proposed workshop, entitled "Aminoacyl-tRNA Synthetases in Biology, Medicine, and Evolution," to be held at the Asilomar Conference, California, from September 23-28, 2001. Owing to the rapid pace of progress and interdisciplinary nature of the synthetase field, organization of this workshop is necessary. The format of the meeting will follow a Gordon Research Conference schedule, with a total of nine formal scientific sessions held in the mornings and evenings. Poster sessions and informal scientific discussions will take place in the afternoons. In each session, major talks of approximately 30 minutes duration will be given by senior investigators, and two to three additional short talks will also be presented by speakers selected on the basis of submitted abstracts. The nine sessions will focus on core issues of tRNA synthetase structure and function, as well as on additional topics of emerging interests. These include the mechanisms of specificity and editing, recognition of tRNA and tRNA-like molecules, alternative functions of synthetases, and artificial aminoacylation systems. This Asilomar meeting represents a unique opportunity to bring together both senior investigators in the field and younger scientists who are still establishing their careers. Participants will be chosen from a highly interactive group of scientists from a variety of disciplines, including representatives from the United States, Europe, and Japan. This is the fourth such meeting to be held in the last decade, with previous meetings held in Autrans, France (1990), Taos, New Mexico (1997), Mittelwihr, France (1998).