FASEB Conference:Vitamin K&Synthesis,Structure,Function

描述(由申请人提供) 这项建议是为了部分支持关于维生素K和维生素的会议 K依赖的蛋白质是在联邦的赞助下举行的 美国实验生物学科学家(FASE B)，2001年8月4日至9日，在 佛蒙特州萨克斯顿河的佛蒙特州学院。这次会议将代表 跨越营养的多学科领域，维生素K在治疗中的应用 干预骨质疏松症和心血管疾病，凝血， 骨骼发育和芋螺毒素GLA神经活性多肽。基本原理 生化和分子机制为同化细菌提供了基础 维生素K介导的生物活性的共同调节参数。 维生素K依赖的羧基酶的知识，结构要求 GLA肽底物与酶的相互作用、前肽和 成熟蛋白质的合成、对维生素K的需求及相互作用 钙结合-GLA结构域与磷脂膜成分一起反映 我们将评估依赖维生素K的蛋白质的共同性质。 会议将集中讨论维生素K研究的最新进展。 参与人数限制为150名申请者，他们将在 在专业知识和能力的基础上，为激励和生产做出贡献 开会。会议将由九个科学会议组成，下午两个 圆桌讨论和海报会议。会议的主要议题是： (1)维生素K与营养；(2)维生素的结构与功能关系 依赖蛋白与膜相互作用，(3)分子机制 介导维生素K依赖的基因表达/发育调控 与衰老有关的蛋白质，(4)基质GLA蛋白质与组织功能，(5)基质 GLA蛋白与心血管疾病，(6)维生素K状况：骨骼 治疗干预的病理生理学，(7)玻璃螺杆菌毒素家族 神经肽和新近发现的含有GLA的蛋白质，(8)家族 维生素K羧基酶，(9)维生素K和华法林。思想交流 这些来自不同领域的调查人员的洞察力将提供 提供新的科学合作机会和新的研究方向 对神经系统、心血管疾病和骨骼疾病的潜在影响。这个 该计划包括该领域的领导者和新/初级调查人员， 博士后研究员和来自欧洲和亚洲的科学家们带来了令人兴奋和 独特的发现。

DESCRIPTION (provided by applicant) This proposal is for partial support of a conference on Vitamin K and Vitamin K-Dependent Proteins that is being held under the auspices of the Federation of American Scientists for Experimental Biology (FASEB) from August 4-9, 2001, at the Vermont Academy in Saxtons River, VT. This conference will represent multi-disciplinary fields spanning nutrition, application of vitamin K for intervention of osteoporosis and cardiovascular disorders, blood coagulation, skeletal development, and the conotoxin Gla neuroactive peptides. Fundamental biochemical and molecular mechanisms provide the basis for assimilating the common regulatory parameters of vitamin K mediated biological activity. Knowledge of the vitamin K dependent carboxylase, the structural requirements of Gla peptide substrate and enzyme interactions, regulation of propeptide and mature protein synthesis, the requirements for vitamin K, and interactions of calcium bound-Gla domains with phospholipid membrane components that reflect the shared properties of the vitamin K-dependent proteins will be evaluated. The meeting will focus on the most recent developments in vitamin K research. Participation will be limited to 150 applicants who will be selected on the basis of expertise and ability to contribute to a stimulating and productive meeting. The conference will consist of nine scientific sessions, two afternoon roundtable discussions, and poster sessions. The major session topics will be: (1) vitamin K and nutrition, (2) structure-function relationships of vitamin dependent proteins and membrane interactions, (3) molecular mechanisms mediating gen expression/developmental regulation of vitamin k dependent proteins with aging, (4) matrix Gla proteins and tissue functions, (5) matrix Gla proteins and cardiovascular disease, (6) vitamin K status: skeletal pathophysiologies an therapeutic intervention, (7) the Conotoxin family of Gla neuropeptides and recently discovered Gla containing proteins, (8) the family of vitamin K carboxylase enzymes, (9) vitamin K and warfarin. Exchange of ideas and insights among these investigators from diverse fields will provide the opportunity for new scientific collaboration and new research directions with potential for impact on neurologic, cardiovascular and bone diseases. The program includes leaders in the field and new/junior investigators, postdoctoral fellows, and scientists from Europe and Asia with exciting and unique findings.