9th International Gastric Proton Transport Conference

该提案要求部分资助将于2001年8月19日至21日在澳大利亚Leura举行的第九届国际质子运输会议“胃质子运输的机制和后果“。这是自1971年以来每3至4年与国际生理科学联合会大会联合召开的系列会议中的第9次。以前的会议在实现目标方面取得了成功，以促进（1）在过去30年中胃分泌生理学和药理学发现的特殊进展，以及（2）通过与胃领域以外的杰出科学家的互动，有效地交叉研究。已出版的前几次会议记录证明了这些成功，据报道，参加各级培训和经验的与会者表现出了热情。会议的组织委员会由胃分泌生理学的著名贡献者以及三位前会议主席组成，包括：放大图片作者：John G.詹姆斯·福特Goldenring，巴里赫斯特，乔治萨克斯，漆谷哲郎（秘书处）.该委员会制定了该计划，并将担任裁判，在选择贡献的摘要介绍和旅行奖励年轻的研究人员。在胃质子泵的分子生物学、细胞分泌功能的调节以及各种药物对胃病理生理的调节方面已经取得了重大进展。会议的主要目标是讨论这些发现的影响，通过密切相关领域的学者的演讲来丰富他们的努力，并为未来的研究和药理学干预的目标制定战略。我们现在知道，幽门螺杆菌在消化性溃疡的发病机制中起着核心作用。这并没有最小化胃酸的作用，而是将焦点集中在疾病的有害因素的协同作用上。为了实现这些目标，一系列的主题将吸引广泛的参与者，并集中在该领域的当前问题，包括（1）H，K-ATP酶的结构和功能-作为药物靶点的分子基础;（2）幽门螺杆菌-分子微生物学和根除策略;（3）小鼠的基因靶向研究-酸分泌和细胞增殖的机制;（4）幽门螺杆菌-分子生物学和分子生物学。（4）壁细胞内的信号传导-活化途径;（5）细胞骨架和膜运输-胃壁细胞作为膜募集的模型。

This proposal requests funds in partial support of the 9th International Proton Transport Conference, "Mechanisms and Consequences of Gastric Proton Transport ", to be held August 19-21, 2001, in Leura, Australia. This is the 9th in a series that has met in association with the Congress of the International Union of Physiological Sciences every 3 to 4 years since 1971. Previous meetings have been distinguished by success in achieving objectives to promote (1) the exceptional progression of discoveries in gastric secretory physiology and pharmacology over the past 30 years, and (2) effective cross fertilization of research through interaction with outstanding scientists working outside the gastric field. Published proceedings of previous meetings attest to these successes as does reported enthusiasm of participants at all levels of training and experience. The Organizing Committee for the Conference is composed of notable contributors to gastric secretory physiology as well as three former Conference chairs, including: Drs. Catherine S. Chew, Gunnar Flemstrom, John G. Forte, James R. Goldenring, Barry Hirst, George Sachs, Tetsuro Urushidani (Secretariat). The Committee developed the program and will act as referees in selecting contributed abstracts for presentation and travel awards to young investigators. There have been major advances in the molecular biology of the gastric proton pump, the regulation of cellular secretory function, and the modulation of gastric pathophysiology by a variety of drugs. The principal objectives of the Conference are to discuss the implications of these findings, to enrich their efforts with presentations by scholars in closely related fields, and to develop strategies for future research and targets for pharmacological intervention. We now know that Helicobacter pylori plays a central role in the pathogenesis of peptic ulcer disease. This has not minimized the role of gastric acid but rather has directed focus on the synergism of injurious factors for the disease. Toward these goals the slate of topics will attract a broad audience of participation and focus current issues in the field, including (1) structure and function of H,K-ATPase - molecular basis as a drug target; (2) Helicobacter pylori - molecular microbiology and strategy for eradication; (3) gene targeting studies in the mouse - mechanisms of acid secretion and cell proliferation; (4) signal transduction in the parietal cell - pathway to activation; (5) cytoskeleton & membrane trafficking - the gastric parietal cell as a model for membrane recruitment.