Mechanisms of Membrane Transport Gordon Conference

基金被要求帮助支持戈登研究会议，膜运输机制，将于2001年6月17日至22日在新罕布什尔州普利茅斯的Holderness学校举行。这次会议延续了非常成功的系列会议，每两年举行一次，主题是膜运输领域的高度兴趣。今年我们将会议的副标题定为“生物学和医学中的膜转运调控”，我们将重点介绍重要膜转运蛋白的转运和功能调控。这一主题具有重大的生物学意义，正如本文所概述的那样，既及时又具有重大的医学意义。这些科目特别与糖尿病和肾功能相关，但也与其他广泛的临床学科有关。会议还将包括膜蛋白结构、膜转运体基因组学和新的生物技术策略方面的相关进展。这自然会把来自各个学科的科学家聚集在一起，促进富有成效的互动，否则这种互动可能永远不会发生。相关学科包括细胞生物学、分子生物学、遗传学、生理学、药理学、生物物理学和内科学。会议的第一部分从细胞生物学的角度进行组织。这反映了一种新兴的观点，即许多转运蛋白的活动，包括通道，在生理上受到它们所遵循的膜运输途径的调节，以被调节的插入和从表面膜中取出而结束。此外，项目组织反映了(1)离子运输调节的新原理已经被发现的事实，(2)具有重要生物医学意义的新运输系统已经被发现的事实，以及(3)新的方法和途径（例如基因组学）允许从根本上对膜运输调节有新的见解。会议包括31场定期报告会、1场全体报告会和4场简短报告会，共分9期进行。演讲者将为各种各样的听众计划他们的演讲，鼓励学生、研究员和临床医生参加。除了计划的讲座外，我们还将在下午和晚上的正式会议之后安排几次“简短的精选讲座”和宣传海报活动，鼓励年轻的研究者和有令人兴奋的新成果的研究者。

Funds are requested to help support a Gordon Research Conference, Mechanisms of Membrane Transport, to be held from June 17-22 in 2001 at Holderness School, Plymouth, New Hampshire. This meeting continues a very successful meeting series, held ever two years, on topical subjects of high interest to the membrane transport field. This year we will subtitle the meeting, Regulation of Membrane Transport in Biology and Medicine, and we will highlight the trafficking and functional regulation of important membrane transporters. This theme is of great biological significance, and as outlined herein, is both timely and of great medical relevance. The subjects are especially relevant to diabetes and kidney function, but also to a wide range of other clinical disciplines. The meeting will also incorporate relevant advances in the structure of membrane proteins, the genomics of membrane transporters, and new biotechnical strategies. This will naturally bring together scientists from a wide range of disciplines and promote fruitful interactions that otherwise would probably never occur. Relevant disciplines include cell biology, molecular biology, genetics, physiology, pharmacology, biophysics, and internal medicine. The first part of the meeting is organized with a cell biological perspective. This reflects an emerging view that activities of many transporters, including channels, are regulated physiologically by the membrane trafficking pathways they follow, ending with regulated insertion into and retrieval from the surface membrane. In addition, the program organization reflects (1) the fact that new principles of ion transport regulation have been discovered, (2) the fact that new transport systems of great biomedical importance have been discovered, and (3) the fact that new methods and approaches (e.g. genomics) are allowing fundamentally new insights into membrane transport regulation. The meeting includes 31 regular talks, 1 plenary lecture, and 4 short talks, organized in 9 sessions. The speakers will plan their talks for a very mixed audience, and the attendance of students, fellows, and clinicians will be encouraged. In addition to the planned lectures, we will encourage young investigators and investigators with exciting new results by scheduling several `short selected talks' and promoting poster sessions to be held in the afternoon and after the formal evening sessions.