A WORKSHOP: POOLED ANALYSIS OF LEAD-EXPOSED COHORTS

描述（摘自研究者摘要） 拟议的讲习班将召集16名调查员， 9月23日召开的一次会议上， 2000年进行汇总分析，并检查铅相关的认知 不足10微克/分升（mcg/dl）。 的优势 实验和人体数据表明， 低水平铅暴露对大脑功能的影响，如减少 智能 有证据表明与铅相关的认知缺陷 接触发生在10微克/分升以下，但最低的血铅浓度 与不良认知影响的相关性尚未确定。 每个 前瞻性研究包括的儿童太少，无法检查任何不利的 血铅浓度< 10 mcg/dl。 然而，总的来说， 是否包括在7个前瞻性队列中接受检查的1,500多名儿童 在汇总分析中。 本次拟议研讨会的目标和分析 是检测与血铅有关的认知缺陷的证据 浓度低于10 mcg/dl，合并现有前瞻性队列。 的 会议将：1。回顾现有的科学文献，表明 血铅浓度低于10%时铅相关的认知缺陷 微克/分升 2.检查血铅浓度与智商（总， 语言和表现），为所有儿童和那些谁有血铅 浓度< 10 mcg/dl、< 5 mcg/dl和< 2.5 mcg/dl。 该研讨会将与第18届国际 神经毒理学会议在科罗拉多斯普林斯，公司的组织者将 完善分析策略以进行汇总分析，制定 关于纳入变量的共识，并定义用于比较的变量 跨研究。 如果拟议分析的结果表明， 铅相关的认知缺陷发生低于10微克/分升，它将提供 认为血铅水平降低的证据 “可接受的”-从10 mg/dl至5 mg/dl或更低。 它也主张， 转向儿童铅暴露的初级预防， 这与目前几乎完全依赖案例的努力形成鲜明对比， 治疗血铅水平升高的儿童。

DESCRIPTION (Taken from the Investigator's Abstract) This proposed workshop is to convene 16 investigators representing 7 international, prospective lead-exposed cohorts for a meeting on September 23, 2000 to conduct a pooled analysis and examine lead-associated cognitive deficits below 10 micrograms per deciliter (mcg/dl). The preponderance of experimental and human data indicate that there are persistent, deleterious effects of low-level lead exposure on brain function, such as diminished intelligence. There is evidence that cognitive deficits associated with lead exposure occur below 10 mcg/dl, but the lowest blood lead concentration associated with adverse cognitive effects had not been defined. Each of the prospective studies have included too few children to examine any adverse effects of blood lead concentration < 10 mcg/dl. Collectively, however, there are over 1,500 children examined in the 7 prospective cohorts to be included in the pooled analyses. The objective of this proposed workshop and analyses is to test for evidence of cognitive deficits associated with blood lead concentrations below 10mcg/dl by pooling existing prospective cohorts. The conference will: 1. Review existing scientific literature that indicates lead-associated cognitive defects at blood lead concentrations below 10 mcg/dl. 2. Examine the relation of blood lead concentration and IQ (total, verbal and performance) for all children and for those who have blood lead concentrations at < 10 mcg/dl, < 5 mcg/dl, and < 2.5 mcg/dl. The workshop will be held in conjunction with the 18th International Neurotoxicology Conference in Colorado Springs, CO. The organizers will refine an analytic strategy to conduct the pooled analysis, develop a consensus about inclusion of variables, and define variables for comparison across studies. If the results of the proposed analyses show that lead-related cognitive deficits occur below 10 mcg/dl, it will provide evidence that argues for a reduction in blood lead levels considered "acceptable" - from 10mg/dl to 5mg/dl or lower. It would also argue for a shift toward the primary prevention of childhood lead exposure, which contrasts sharply with current efforts that rely almost exclusively on case management of children with elevated blood lead levels.