Visual Attention Selection Negativity in Schizophrenia

精神分裂症是一种毁灭性的精神疾病，包括患者分配和维持对行为相关信息的注意力的能力严重障碍。尽管注意障碍是精神分裂症患者特有的认知缺陷和一般信息处理障碍的根本原因之一，但这些缺陷的潜在神经生理学基础尚不清楚。许多研究试图描述精神分裂症患者神经解剖视觉通路的病理生理学特征。其中许多研究结果都表明，大细胞系统的功能失调可能会导致工作记忆、执行功能和注意力的高级认知缺陷。这个项目的总体目标是利用神经活动的电生理和功能神经成像手段来描绘精神分裂症患者选择性视觉注意缺陷的神经解剖学和时间基础，特别是这些缺陷如何与大细胞和小细胞视觉通路中的感觉处理有关。

Schizophrenia is a devastating mental illness that includes severe disturbances in patients' ability to allocate and sustain attention on behaviorally relevant information. Although attentional dysfunction is one of the root causes of the cognitive deficits and general impairments in information processing that are characteristic of persons afflicted with schizophrenia, the underlying neurophysiological substrates of these deficits are poorly understood. Numerous studies have attempted to characterize pathophysiology in the neuroanatomical visual pathways of schizophrenia patients. The findings from many of these converge to suggest that dysfunctional processing of the magnocellular system may give rise to subsequent high-order cognitive deficits in working memory, executive functioning and attention. The overall goal of this project is to utilize electrophysiological and functional neuroimaging measures of neural activity in order to delineate the neuroanatomical and temporal bases of selective visual attention deficits in schizophrenia patients and, in particular, how these deficits relate to sensory processing within the magnocellular and parvocellular visual pathways.