HIGHLY ACTIVE ANTIRETROVIRAL THERAPY AND LYMPHOID IRRADIATION IN HIV DISEASE

这项研究是旨在评估胸腺在艾滋病毒疾病中的作用的系列研究的第二项，并利用高效的抗逆转录病毒治疗来抑制病毒的复制和在胸腺内的传播。然后，研究人员将启动研究，以测试全淋巴照射(TLI)是否可能有助于降低全身病毒载量，并促进胸腺外周的重新繁殖。通过保护胸腺免受这种辐射的影响，并同时进行高活性的抗逆转录病毒治疗，可以消除外周淋巴系统中受感染的T细胞和黏液细胞，可以抑制幸存受感染细胞的病毒传播，并可以用从胸腺迁出的幼稚T细胞重新填充外周系统。这项研究的主要目的是测试这种方法的安全性和可行性，并提供病毒学、免疫学和临床参数的广泛评估。

This study is a second in a series designed to evaluate the role of the thymus in HIV disease and utilizes highly active anti-retroviral therapy to suppress viral replication and spread within intrathymic compartments. The investigator will then initiate studies to test the possibility that total lymphoid irradiation (TLI) may serve to reduce the total body viral load and facilitate thymic repopulation of the periphery. By shielding the thymus from the effects of such radiation and by administering highly active anti-retroviral therapy concomitantly, infected T and myloid cells in the peripheral lymphoid system may be eliminated, viral spread from surviving infected cells may be suppressed, and the peripheral system may be repopulated with naive T-cells emigrating from the thymus. This study is primarily designed to test the safety and feasibility of such approach as well as to provide extensive evaluation of virologic, immunologic, and clinical parameters.