Outcomes of Education and Counseling for BRCA1/2 Testing

这项研究的目标是：1)确定对BRCA1测试的个人决策有显著影响的家庭特征和个性特征和信念，如宗教和精神信仰以及以前与癌症有过直接接触；2)表征BRCA1测试结果阴性和阳性对家庭关系和心理状况的影响；3)根据个人性格特征预测对风险状况的具体咨询的反应；4)预测谁最有可能对亲密关系产生负面影响；5)评估对测试的期望，以及这些因素如何影响对风险的感知和对风险通知的反应；6)评估风险通知对监测和预防活动频率的影响；7)将客户驱动的测试前会话与顾问驱动的、解决问题的方法进行比较。到目前为止，已经联系了来自11个大家庭的556人。256人(46%)参与了这项研究，220人(86%的咨询者)选择接受基因测试。173人已经收到了他们的检测结果。对测试决定的预测因素进行了分析，包括社会人口统计学和人格特征。年龄、婚姻状况、家庭凝聚力和乐观性是接受测试的决定的预测因素。目前正在提交这些基线结果以供公布。-乳腺癌-人类受试者

The objectives of the study are; 1) to identify family characteristics and personality traits and beliefs that significantly effect individual decisions regarding BRCA1 testing such as, religious and spiritual beliefs and previous direct experience with cancer; 2) to characterize the impact of negative vs. positive BRCA1 testresults on family relationships and psychological status; 3) to predict responses to specific counseling regarding risk status based on individual personality profiles; 4) to predict who is at greatest risk for experiencing negative effects on close relationships; 5) to assess expectations regarding testing and how these influence perceptions of risks and responses to risk notification; 6) to evaluate the impact of risk notification on the frequency of surveillance and prevention activities; and 7) to compare a client-driven pre-test session to a counselor-driven, problem-solving approach. To date, 556 individuals from eleven extended families have been contacted. Two hundred fifty six (46%) have participated in the study and 220 (86% of those counseled) have chosen to undergo genetic testing. One hundred seventy three individuals have received their test results. Predictors of testing decisions including, sociodemographics and personality traits have been analyzed. Age, marital status, family cohesion and optimism are predictive of the decision to be tested. These baseline results currently are being submitted for publication. - Breast Cancer - Human Subjects