Virtual Reality Cue Exposure for Drug Addiction: Smoking

描述(由研究人员提供)：这项研究将开发和测试虚拟现实线索暴露(VRCE)治疗药物成瘾的可行性：吸烟。传统的线索暴露包括将受试者带入严酷的实验室环境，并使用照片、视频或设备来引发反应。虽然传统的方法会导致反应，但这种类型的线索暴露到治疗计划中的推广仍然存在疑问。虚拟现实曝光(VRE)将计算机图形与感官输入设备相结合，包括：跟踪设备、可视头盔显示器(HMD)和旨在使参与者沉浸在计算机生成的虚拟环境中的定向音频。针对药物成瘾的VRCE将在安全、保密和受控的实验室或办公室环境中，将虚拟现实的元素与特定的药物线索、环境、与药物有关的社交互动和其他相关刺激结合起来。VRCE将视频图像和对复杂线索的暴露相结合，可以扩展传统的线索暴露(反应性)方法，并提供比传统方法明显的优势。该项目将重点开发VRCE，将计算机生成的图像和描述吸烟提示(例如香烟包装、烟灰缸、燃烧的香烟)和吸烟社交互动(例如在社交环境中被提供香烟)的视频图像结合在一起。VRCE的可行性将在一项针对吸烟者的临床试点研究中进行测试。20名尼古丁依赖吸烟者将同时暴露在VR中性刺激和VR药物刺激下。生理唤醒和自我报告的渴望将在VR中性刺激和VR药物刺激之间进行比较。该项目的目的是为尼古丁依赖吸烟者开发和试点测试VRCE。长期目标是开发和测试VRCE，并开发负担得起的交钥匙VRCE系统，该系统将用于药物滥用项目、个人治疗师、医院和尼古丁和其他滥用药物的成瘾研究人员的商业使用。

DESCRIPTION (provided by investigator): This study will develop and test the feasibility of virtual reality cue exposure (VRCE) for drug addiction: Smoking. Traditional cue exposure has involved bringing persons into an austere laboratory environment and using photos, video, or paraphernalia to elicit reactions. While traditional approaches result in reactions, generalization of this type of cue exposure into treatment programs remains in question. Virtual reality exposure (VRE) combines computer graphics with sensory input devices including: tracking devices, visual head mounted displays (HMD), and directional audio designed to immerse a participant in a computer generated virtual environment. VRCE for drug addiction would combine the elements of VR with specific drug cues, environments, drug related social interactions, and other associated stimuli in the safe, confidential and controlled lab or office setting. VRCE combining video images and exposure to complex cues can expand traditional cue-exposure (reactivity) approaches and offer distinct advantages over traditional approaches. This project will focus on the development of a VRCE combining both computer generated and video images depicting smoking cues (e.g. cigarette packages, ash trays, burning cigarette) and smoking social interactions (e.g. being offered a cigarette in a social context). The feasibility of VRCE will be tested in a clinical pilot study with cigarette smokers. Twenty nicotine dependent smokers will be exposed to both VR neutral stimuli and VR drug stimuli. Physiological arousal and self-reported craving will be compared between the VR neutral and VR drug stimuli. The aim of this project is to develop and pilot test VRCE for nicotine dependent cigarette smokers. The long-term goal is to develop and test the VRCE, and develop affordable turnkey, VRCE systems that will be commercially available to substance abuse programs, individual therapists, hospitals, and drug addiction researchers for nicotine and other drugs of abuse.