Development of Etched Modified Capillaries

描述(由申请人提供)：这份STTR建议书描述了圣何塞州立大学和Microsolv Technology Corporation之间的一个合作项目，该项目旨在开发和营销用于毛细管电泳法和相关技术的蚀刻改性毛细管。开发的重点涉及一种用二氟化氢铵腐蚀熔融二氧化硅毛细管的格式，然后通过将有机部分附着到毛细管壁或通过物理涂覆聚合物或表面活性剂进行化学修饰。键合过程利用硅烷化/硅氢化方法，以稳定的硅-碳键连接有机部分。这些材料可能的应用涉及药物、多肽和蛋白质。通过Microsolv与一些工业实验室之间的合作安排，将测试蚀刻的改性毛细管在实际应用中的实用性。圣何塞州立大学的主要开发工作将继续进行，以改进现有的格式，并为更广泛的应用制造新材料，或回应工业实验室测试的反馈。Microsolv公司将实施一项营销计划，将产品分销给在目标应用领域工作的公司使用。

DESCRIPTION (provided by applicant): This STTR proposal describes a collaborative project between San Jose State University and Microsolv Technology Corporation for the development and marketing of etched modified capillaries for use in capillary electrophoresis and related techniques. The focus of the development involves a format for etching fused silica capillaries with ammonium hydrogen difluoride followed by chemical modification through attachment of an organic moiety to the capillary wall or by physically coating a polymer or surfactant. The bonding process utilizes the silanization/hydrosilation method in order to attach the organic moiety with a stable silicon-carbon linkage. The likely applications of these materials involve pharmaceuticals, peptides and proteins. Through cooperative arrangements between Microsolv and a number of industrial labs, the etched modified capillaries will be tested for their usefulness in practical applications. The major development work will continue at San Jose State in order to improve on the formats currently available as well as to fabricate new materials for a broader range of applications or in response to feedback from the industrial lab tests. Microsolv Corporation will undertake a marketing plan to distribute the products for use by companies working in the targeted application areas.