CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN I

载脂蛋白A-I(apoA-I)是 人类血液中发现的高密度脂蛋白(高密度脂蛋白)颗粒。高 高密度脂蛋白水平，特别是高密度脂蛋白的载脂蛋白A-I含量 与动脉粥样硬化风险的降低相关，因此降低 有患冠状动脉疾病的风险。载脂蛋白A-I也在 激活血浆酶组装高密度脂蛋白颗粒 卵磷脂-胆固醇酰基转移酶(LCAT)。我们需要同步加速器 用于收集高分辨率数据的辐射，因为这种结构具有 载脂蛋白A-I如何与高密度脂蛋白中的脂质结合的深刻含义。

Apolipoprotein A-I (apoA-I) is the major protein component of high-density lipoprotein (HDL) particles found in human blood. High levels of HDL, and especially the apoA-I content of HDL, strongly correlate with a reduced risk of atherosclerosis, and hence a reduced risk of coronary artery disease. ApoA-I also plays a key role in the assembly of HDL particles by activating the plasma enzyme lecithin-cholesterol acyl transferase (LCAT). We need synchrotron radiation to collect high-resolution data as this structure has profound implications for how apoA-I binds to lipid in HDL.