Multi modal imaging for the assessment of morphological changes in biological systems after chemical intervention

该项目将开发技术和方法，以加强生物系统产生的数据，并将外源和内源化学物种对这类系统的影响直接联系起来。该项目将利用光学、电子、分子显微镜和质谱学成像技术。这种多模式方法的目标是最大限度地提供有关化学干预对生物系统影响的信息。将探索的较新的模式之一将是用于成像有机物的光片显微镜，从而允许实时评估形态变化。

The project will develop techniques and methodologies to enhance data generated from biological systems and directly correlate the effects of exogenous and endogenous chemical species on such systems. The project will utilise optical, electron, molecular microscopy and mass spectrometry imaging. The goal of such a multi-modal approach is to maximize information on the effect of chemical intervention on the biological system. One of the noveler modalities that will be explored will be light sheet microscopy for imaging organoids, allowing the assessment of morphological changes in real time.