BABOON RESEARCH RESOURCE PROGRAM

此P40补助金申请建议扩大和加强狒狒 俄克拉荷马州大学健康科学中心 （OUHSC）。OUHSC已经维持了40多年的狒狒设施。我们 狒狒研究计划从一个小部门运作到一个计划 支持三所健康学院的研究人员， 科学中心，两个非营利性研究机构对俄克拉荷马州 卫生中心校区是三所大学的主要医学教学和 俄克拉荷马州的研究机构和10个医疗中心 分布在美国各地。狒狒正被用于一个不断增长的 一些生物医学研究，但其可用性是有限的;他们是 在现有的灵长类动物繁殖计划和进口中代表性不足 从野外采集是昂贵的，困难的，严格的健康监管 原因由于OUHSC已成为可靠的狒狒资源，我们 认识到需要扩大和提高生产力。 我们建议通过增加我们的工作人员来加强我们的研究计划， 建立一个新的繁殖设施该设施由大学支持， 基金，将设在7,000英亩的美国农业部牧场研究 车站位于俄克拉荷马州埃尔雷诺附近的OUHSC以西30英里处。在那里， 我们将为狒狒提供一个更自然的环境 在大型户外围栏中繁殖群体。加入一个非人类 灵长类动物生殖行为学家和兽医动物遗传学家将 提供专业知识，以帮助提高我们的生产力。灵长 行为学家将对狒狒的生殖行为进行研究 以及生物学，它将识别任何生殖问题， 他们她还将指导一项环境富集计划。我们将 表征殖民地的病毒状态，并形成 狒狒的特定病原体无繁殖计划，以建立 在俄克拉荷马州州立大学兽医学院， 俄克拉荷马州的斯蒂尔沃特。 这项研究资源计划将加强和扩大非人类 生物医学和行为研究在OUHSC，刺激增加 区域研究机构之间的合作，并建立OUHSC 作为一个国家认可的狒狒作为研究对象的供应商。

This P40 grant application proposes to expand and enhance the Baboon Resource Center at the University of Oklahoma Health Sciences Center (OUHSC). The OUHSC has maintained a baboon facility for over 40 years. Our baboon research program from a small department operation to a program that supports research investigators in three colleges of the Health Sciences Center, two non-profit research institutions on the Oklahoma Health Center Campus, the three main university medical teaching and research institutions in the State of Oklahoma, and 10 medical centers located throughout the United States. Baboons are being used in a growing number of biomedical studies, yet their availability is limited; they are under-represented in existing primate breeding programs and importation from the wild is expensive, difficult, and strictly regulated for health reasons. As the OUHSC has become a reliable baboon resource, we have recognized a need to expand and improve productivity. We propose to enhance our research program by increasing our staff and creasing a new breeding facility. The facility, supported by University funds, will be located at the 7,000 acre USDA Grazinglands Research Station located 30 miles west of the OUHSC near El Reno, Oklahoma. There, we will provide a more naturalistic environment for maintaining the baboon breeding colony in large outdoor corrals. The addition of a non-human primate reproductive behaviorist and a veterinary theriogenologists will provide expertise to assist in increasing our productivity. The primate behaviorist will conduct research studies on baboon reproductive behavior and biology which will identify any reproduction problems and ameliorate them. She will also direct an environmental enrichment program. We will characterize the viral status of the colony and develop a nucleus of baboons for a specific-pathogen-free breeding program, to be established at the Oklahoma State University College of Veterinary Medicine in Stillwater, Oklahoma. This research resource program will strengthen and expand non-human biomedical and behavioral research at the OUHSC, stimulate increased cooperation among regional research institutions, and establish the OUHSC as a nationally-recognized provider of baboons as a research subject.