Increasing Housing Capacity of the Rodent Barrier Facility

说明(申请人提供)：这项拨款申请要求拨款购买额外的通风笼架，以满足新的啮齿动物屏障设施(RBF)对笼子空间的持续需求。俄克拉荷马大学健康科学中心(OUHSC)共有53项有效资助和23项悬而未决的资助，涉及啮齿动物项目，这些项目因安置在屏障设施中而受益匪浅。OUHSC确定了四个研究重点领域，包括癌症、糖尿病、神经科学/视力和传染病。转基因和基因敲除啮齿动物的利用需要更新啮齿动物研究资源设施。美国国立卫生研究院C06拨款部分资助了新的啮齿动物屏障设施。C-06提供了400万美元的支持，大学提供了设施建设资金的余额，总计超过1000万美元。该大学还出资购买了24个老鼠通风架和8个老鼠通风架，费用为872,000美元。随后，该大学又出资118000美元，为另外6个老鼠通风支架提供了经费。政府为一名兽医和工作人员增设了一个全职职位，并为其提供资金，以加强啮齿动物计划。我们在隔离墙上的啮齿动物数量迅速增加。这一增长既是转基因和基因敲除啮齿动物群体重新衍生的结果，也是利用啮齿动物的新教师招聘的结果。正在招聘教员以填补18个新的捐赠研究教授职位，进一步增加了对RBF更大住房能力的需求。

DESCRIPTION (provided by applicant): This grant application request funds for the purchase of additional ventilated cage racks to meet the continuing demand for cage space in the new Rodent Barrier Facility (RBF). The Oklahoma University Health Sciences Center (OUHSC) has a total of 53 active grants and 23 pending grants involving rodent programs that benefit greatly from being housed in a barrier facility. The OUHSC has identified four areas of research concentration which includes cancer, diabetes, neurosciences/vision and infectious diseases. Utilization of both transgenic and knockout rodents has necessitated an update in rodent research resource facilities. An NIH C 06 grant partially funded the new Rodent Barrier Facility. The C-06 provided four million dollars in support and the University supplied the balance of the funds for construction of the facility totaling over ten million dollars. The University also funded the purchase of 24 ventilated racks for mice and eight ventilated racks for rats at a cost of $872,000 dollars. Subsequently six additional rat ventilated racks were funded by the University at a cost of $118,000. The administration created and funded an additional full time position for a veterinarian and staff to augment the rodent program. Our population of rodents in the barrier has increased at a rapid pace. This growth is the result of both rederivation of transgenic and knockout rodent colonies and recruitment of new faculty that utilize rodents. Faculty are being recruited to fill 18 new endowed research professorship positions further increasing the need for a larger housing capacity in the RBF.