BABOON RESEARCH RESOURCE PROGRAM

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。描述（由申请人提供）：本次P40竞争性更新提议延续最初拨款申请的目标，并扩大对使用狒狒作为生物医学和行为研究模型的研究人员的支持。研究人员不仅完成了最初拨款建议的目标，而且随着2002年7月R24的授予，研究人员现在正在开发SPF狒狒资源。OU Fort Reno科学园设施于2001年3月完工，并于2001年夏天全部占用。该设施提供4个0.5英亩的室外围栏和8个大型室内围栏，供狒狒群体居住。畜栏配有大型攀爬结构和混凝土涵洞。这里有足够的空间让庞大的多雄性狒狒群体展现出物种的典型行为。每组有3只成年雄性狒狒和25到30只成年雌性狒狒及其幼崽和幼崽。这种社会安排是野生Papio (P.) anubis的典型特征。在需要进行研究之前，它们的后代会和父母一起待在畜栏里。许多被分配参加研究的动物在研究期结束后被送回它们自己的畜栏。这种情况是大多数疫苗方案的特点；狒狒被一组一组地从里诺堡的畜栏中移出，在研究期间作为一组被安置在动物资源附件中，然后作为一组返回到里诺堡的设施。幼鲸可以在同一个畜栏里待到青春期。这个狒狒群落已经从四年前P40基金开始支持时的141只狒狒增长到284只狒狒，其中包括126只成年雌性狒狒，14只成年雄性狒狒和149只幼崽和幼崽。调查人员目前在里诺堡的设施里安置了12只雄性，115只成年雌性以及它们的婴儿和幼崽。在最后一个拨款年度，研究人员向OUHSC和外部研究人员提供了52只狒狒。研究人员发表了18篇文章，并在资助期的最后四年里支持了美国国立卫生研究院（NIH）资助的12个外部机构的研究项目。为了容纳越来越多的传统狒狒，未来的计划包括在目前的Fort Reno设施上增加四个新的畜栏。其他计划包括建造一个单独的、有六个畜栏的单元来容纳SPF狒狒。研究人员正在增加另外两名共同研究人员，他们将扩大基于资源的研究。uiel Blas-Machado， D.V.M, Ph.D.将描述寄生原生动物溶组织内阿米巴原虫（E.），这种原虫在该种群和世界上许多狒狒种群中都是地方性的。Blas-Machado博士将得到明尼苏达大学医学院医学部主席Jonathan Ravdin医学博士的协助。Ravdin博士是溶组织芽胞杆菌的专家，并获得了美国国立卫生研究院的资助，开发了一种用于人类的口服疫苗，以保护人类免受这种有机体的侵害。俄克拉荷马州立大学兽医病理学家William A. Meier博士将与加州国家灵长类动物研究中心的Ronald Kennedy博士和Christopher J. Miller博士合作，开发试剂和方法，以评估狒狒对传染性病原体的细胞体液和细胞免疫反应。主要任务是为美国国立卫生研究院资助的研究人员提供健康和行为正常的生物医学和行为研究狒狒。调查人员将提供两种选择，要么出售狒狒，要么租赁狒狒，收取使用费，最终返回繁殖地。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): This P40 competitive renewal proposes to continue the aims of the initial grant application and expand the support of research investigators using baboons as models in biomedical and behavioral research. Not only have the investigators accomplished the aims of the initial grant proposal, but with the award of the R24 in July 2002 the investigators are now developing the SPF Baboon Resource. The OU Fort Reno Science Park Facility was completed in March of 2001 and became fully occupied by the summer of 2001. The facility provides four 0.5 acre outdoor corrals and eight large indoor gang cages for the group housing of baboons. The corrals are equipped with large climbing structures and concrete culverts. There is ample room for the large, multiple-male groups of baboons to exhibit species-typical behavior. Three adult males and from 25 to 30 adult female baboons with their infant and juvenile offspring populate each group. This social arrangement is typical for Papio (P.) anubis in the wild. The offspring remain in the corrals with their parents until they are needed for research. Many animals assigned to studies are later returned to their home corrals after the study period is completed. This scenario is characteristic of most vaccine protocols; baboons are removed in a group from a corral at Fort Reno, housed as a group at the Animal Resources Annex for the duration of the study, and then returned to as a group to the Fort Reno facility. The juveniles can remain together in the same corral until they reach puberty. The baboon colony has grown from 141 baboons at the outset of the P40 Grant support four years ago, to a colony of 284 baboons including 126 adult female baboons, 14 adult males, and 149 infants and juveniles. The investigators are presently housing 12 males, 115 adult females and their infant and juvenile offspring at the Fort Reno facility. During the last grant year, the investigators supplied 52 baboons to both OUHSC and outside research investigators. The investigators have published 18 articles and have supported National Institutes of Health (NIH) funded research programs at 12 outside intuitions during the last four years of the funding period. In order to accommodate increasing numbers of conventional baboons, the future plans include adding four new corrals to the present Fort Reno Facility. Additional plans include the construction of a separate, six-corral unit to house the SPF baboons. The investigators are adding two additional co-investigators who will expand the resource-based research. Uriel Blas-Machado, D.V.M., Ph.D., will characterize the parasitic protozoa Entamoeba (E.) histolytica that is endemic in the colony and in many colonies of baboons throughout the world. Dr. Blas-Machado will be assisted by the collaboration of Jonathan Ravdin, M.D., Chairman, Department of Medicine, University of Minnesota, College of Medicine. Dr. Ravdin is an expert in E. histolytica and has NIH funding to develop an oral vaccine for humans for protection from the organism. William A. Meier, D.V.M., Ph.D., Veterinary Pathologist at Oklahoma State University, will work with Dr. Ronald Kennedy and Dr. Christopher J. Miller, California National Primate Research Center, to develop reagents and methodologies to assess the cellular humoral and cellular immune response of baboons to infectious agents. The primary mission is to provide healthy and behaviorally normal baboons for biomedical and behavioral research to NIH-funded researchers at institutions across the United States. The investigators will offer the option of either selling baboons or leasing them for a use fee and ultimate return to the breeding colony.