TRAINING IN INTEGRATIVE CARDIOVASCULAR BIOLOGY

描述（申请人摘要）本申请是在格鲁吉亚的我学院的综合心血管生物学的一个新的博士后培训补助金。该项目的长期目标是培养博士后博士。和医学博士研究员在综合心血管生物学的独立基础研究事业，利用技术跨越分子，遗传，细胞组织/器官和整个动物/人的范围。 这是一个跨部门和跨学科的计划，结合了20名教师的专业知识，在神经病学，病理学，儿科学，药理学，生理学，格鲁吉亚预防研究所，分子医学和遗传学研究所和血管生物学中心在格鲁吉亚的医学学院的部门。 该计划的教师导师代表了一个杰出的综合心脏和血管：生物学家，其研究兴趣涵盖五个相关的心血管领域：1）血管细胞信号传导，2）血管张力控制，3）心脏发育，4）内皮功能障碍，5）预防心血管疾病。这项培训补助金将通过医学院血管生物学中心管理。 该项目由约翰·D博士主持。Catravas，项目主任和弗兰克Treiber博士，项目联合主任，都建立和调查。 Catravas博士是血管生物学中心的主任，Treiber博士是格鲁吉亚预防研究所的主任。 一个由格鲁吉亚医学院高级院士和领导人组成的内部咨询委员会将监督该项目。受训者将获得博士学位，M.D.或医学博士/博士博士后科学家 第一年的三个博士后职位和第2-5年的六个职位被要求支持研究员从事综合心血管生物学的全职研究。 每位学员将接受2-3年的研究培训。博士博士后学员将对基础综合心血管生物学有长期的职业兴趣。M.D. M.D.博士学员将完成为期五年的住院医生/专科训练。 所有受训人员都必须参加教学培训活动，其中包括血管生物学基础科学系列讲座、科学交流和研究伦理课程、血管生物学中心系列研讨会、期刊俱乐部、年度研究专题讨论会和博士后研究员协会。 此外，M.D.学员须修读研究统计学的研究生课程。 该培训计划坚定地致力于增加接受心血管研究培训的代表性不足的少数民族和妇女的数量。研究培训设施包括20名导师的个人实验室，以及血管生物学中心，格鲁吉亚预防研究所，分子医学和遗传学研究所心脏发育组，神经学，生理学和药理学系的核心实验室，以及分子生物学，组织学，转基因分析，转基因和胚胎干细胞，流式细胞术和细胞成像，包括超过100，000平方英尺。在两个相邻的建筑和一个相邻的建筑中的研究空间。 培训计划完成后，学员将被指导申请独立研究经费，并在学术医学院从事心血管科学独立研究者的职业。

DESCRIPTION (Applicant's Abstract) This application is for a new post-doctoral training grant in integrative cardiovascular biology at the Me College of Georgia. The long-term objective of this program is to train post-doctoral Ph.D. and M.D. fellows for independent basic research careers in integrative cardiovascular biology, utilizing techniques spanning the molecular, genetic, cellular tissue/organ and whole animal/man range. This is an interdepartmental and interdisciplinary program incorporating the expertise of 20 faculty in the Departments of Neurology, Pathology, Pediatrics, Pharmacology, Physiology, the Georgia Prevention Institute, the Institute of Molecular Medicine and Genetics and the Vascular Biology Center at the Medica College of Georgia. The faculty preceptors of the program represent an outstanding group of integrative cardiac and vascular: biologists whose research interests cover five related cardiovascular areas: 1) vascular cell signaling, 2) control of vascular tone, 3) cardiac development, 4) endothelial dysfunction, and 5) prevention of cardiovascular disease. This training grant will be administered through-the Vascular Biology Center of the School of Medicine. The program is directed by Dr. John D. Catravas, Program Director and Dr. Frank Treiber, Program Co-Director, both establish & investigators. Dr. Catravas is the Director of the Vascular Biology Center and Dr. Treiber is the Director of the Georgia Prevention Institute. An Internal Advisory Committee of senior academicians and leaders at the Medical College of Georgia will supervise the program. Trainees will be Ph.D., M.D. or M.D./Ph.D. post-doctoral scientists. Three post-doctoral slots in the first year and six slots in years 2-5 are requested to support fellows pursuing full-time research in integrative cardiovascular biology. Each trainee will commit to 2-3 years of research training. Ph.D. post-doctoral trainees will have long term career interests in basic integrative cardiovascular biology. M.D. and M.D./Ph.D. trainees will have completed a combined 5 years of residency/sub- specialty training. All trainees will be required to participate in didactic training activities, which consist of a basic science lecture series in Vascular Biology, a course in Scientific Communications and Research Ethics, the Vascular Biology Center seminar series, a journal club, an annual research symposium and the Post-Doctoral Fellows Association. In addition, M.D. trainees will be required to take the graduate course in Research Statistics. The training program is strongly committed to increasing the number of under represented minorities and women who receive training in cardiovascular research. Facilities for research training include the individual laboratories of the 20 preceptors in, and the core laboratories of, the Vascular Biology Center, the Georgia Prevention Institute, the Heart Development Group of the Institute of Molecular Medicine and Genetics, the Departments of Neurology, Physiology and Pharmacology, as well the outstanding institutional Core Facilities in Molecular Biology, Histology, Transgenic Analysis, Transgenic and Embryonic Stem Cell, Flow Cytometry and Cell Imaging, encompassing in excess of 100,000 sq.ft. of research space in two contiguous and one adjacent buildings. Upon completion of the training program, trainees will be guided to apply for independent research funding and to pursue careers as independent investigators in cardiovascular sciences at academic medical schools.