BASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASES

这是一个新的培训计划，以支持6名博士后学员（医学博士）的申请。和/或博士学位）和6名博士生（M.D./博士）重点是细胞和分子生物学/基因治疗的免疫学。博士后和博士前研究生的平均培养期分别为3年和4年。13名经验丰富的导师将在高度活跃和互动的研究实验室提供广泛的培训，这些实验室致力于对各种人类疾病的细胞，分子生物学和免疫学方面的基本方面进行最先进的研究，并为其中一些疾病开发诺埃尔基因治疗方法的前景。大多数导师都住在新建或翻新的宽敞的实验室在微生物学和免疫学系;血液学/肿瘤学部，医学系;医学和分子遗传学系;赫尔曼B威尔斯中心儿科研究，儿科系;和瓦尔特肿瘤中心，在三个相邻的建筑物。同行评审的出版物和每一位导师的校外资助的良好记录是拟议培训计划的主要优势。由于各种导师之间积极、持续的科学合作，存在着进行多学科研究的充分机会。一个重要的重点是促进和促进下一代生物医学研究人员的发展，致力于学术医学的科学事业，成为独立的调查人员，反过来，他们本身也将是富有成效和竞争力的。已经为工作人员和访问科学家制定了多管齐下的办法;正式和非正式的课程和研讨会;实验室会议;以及参加州、国家和国际科学会议，并将进一步予以强调。与实验室建立联系的决定将由受训者和导师双方同意作出，受训者的科学发展将由一个由具有多学科研究兴趣的导师组成的研究委员会促进。可用的主要资源包括国际公认的临床和基础科学研究项目，美国仅有的三个NIH指定的国家基因载体实验室之一，最先进的基础设施，并与布卢明顿的印第安纳州大学，西拉斐特的普渡大学的活跃调查人员经常接触，所有这些都在附近，以及国内和国际上的其他调查人员。

This is a new application for a training program to support 6 postdoctoral trainees (M.D. and/or Ph.D.) and 6 predoctoral students (M.D./Ph.D.) per year with a strong emphasis on cell and molecular biology/immunology of gene therapy. The average training period for postdoctoral and predoctoral students will be 3 years and 4 years, respectively. Thirteen well-established preceptors will provide extensive training in highly active as well as interactive research laboratories pursuing state of the art research on fundamental aspects of cellular, molecular biological, and immunological aspects of a variety of human diseases, and the prospects of developing noel gene therapy approaches for some of these disorders. Most of the preceptors are housed in newly built or renovated spacious laboratories in the Department of Microbiology and Immunology; Division of Hematology/Oncology, Department of Medicine; Department of Medicinal and Molecular Genetics; Herman B Wells Center for Pediatric Research, Department of Pediatrics; and the Walther Oncology Center, in three adjoining buildings. Strong track-records of peer-reviewed publications and extramural funding of each of the preceptors a major strength of the proposed training program. Ample opportunities for pursuing multi- disciplinary research exist due to active, ongoing scientific collaborations among various preceptors. A significant emphasis is placed to promote and foster the development of the next generation of biomedical researchers committed to scientific careers in academic medicine to become independent investigators who, in turn, will themselves be productive and competitive. A multi-pronged approach for staff members and visiting scientists; formal and informal courses and seminars; laboratory meetings; and participation in state, national and international scientific meetings, is already in place and will be further emphasized. The decision to associate with a laboratory will be made by mutual consent of the trainee and the preceptor, and the scientific development of the trainee will be facilitated by a research committee composed of preceptors with multi-disciplinary research interests. Major resources that are available include internationally recognized clinical and basic science research programs, one of only three NIH-designated National Gene Vector Laboratories in the U.S., state of the art infrastructure, and frequent contacts with active investigators at Indiana University in Bloomington, Purdue University in West Lafayette, all in close proximity, and other investigators nationally as well as internationally.