TETANUS TOXIN MONOLAYER CRYSTAL

我们再次努力进行结构分析， 在磷脂上生长的破伤风毒素沿着 天然神经节苷脂配体。 我们之前的分析表明， 获得超过10的高分辨率图像数据的可能性
使用 泛光束照明 我们计划改变结晶 获得更有序的二维晶体的条件和使用 点扫描成像以获得更好的图像。 我们觉得这个项目 有潜力成为高新技术产业发展的核心项目 分辨率二维晶体结构分析代替 crotoxin复合晶体核心项目已被终止。 的 这个项目的意义部分在于解决了一个未知的蛋白质 结构和部分显示的可行性，确定高 蛋白质晶体的三维结构 磷脂单层。

We have renewed our effort to pursue the structural analysis of the tetanus toxin which was grown on the phospholipid along with its natural ganglioside ligand. Our previous analysis suggested the possibility of obtaining high resolution image data beyond 10
using flood beam illumination. We plan to vary the crystallization condition to obtain more ordered two-dimensional crystals and to use spot-scan imaging to obtain better images. We feel that this project has a potential to become a core project for the development of high resolution two-dimensional crystal structure analysis in place of the crotoxin complex crystal core project which has been terminated. The significance of this project is partly to solve an unknown protein structure and partly to show the feasibility of determining the high resolution three-dimensional structure of protein crystals grown on phospholipid monolayers.