DIFFUSION TENSOR MEASUREMENT OF GUINEA PIG LUNG AIRWAYS USING HYPERPOLARIZED 3HE

开发小鼠体内成像的特定技术 用磁共振显微镜。这将主要涉及确定动物 搬运程序、通风和麻醉要求 成像。这项使用普通鼠标的工作是为未来做准备 利用小鼠进行发育和毒理学研究。这个 小鼠已被广泛用作许多病理和疾病的模型。 基因研究。使用更高分辨率的磁共振显微镜，如 我们用于活体成像的9T系统要求动物不是 比一只20到30克的老鼠还大。目前，我们无法想象 这只小动物是因为我们对动物的支持能力有限 和监控系统。本项目提出要解决这些问题。 并使对老鼠进行非侵入性的存活成像成为可能。 这种对这种小动物进行成像的能力将使我们有可能 在这方面做了许多重要的基础和体内应用研究 研究动物。

To develop specific techniques for in vivo imaging of the mouse with MR microscopy. This will primarily involve determining animal handling procedures, ventilation, and anesthesia requirements for imaging. This work with the normal mouse is in preparation for future studies using mice for developmental and toxicologic studies. The mouse has been used extensively as a model for many pathologies and in genetic studies. the use of higher resolution MR microscopes such as our 9 T system for in vivo imaging requires that the animal be no bigger than a 20 to 30 g mouse. Currently, we are not able to image this small an animal because of the limitation of our animal support and monitoring systems. This project proposes to solve these problems and make it possible to do non-invasive, survival imaging of mice. This capability of imaging such small animals will make it possible to do many important basic and applied in vivo studies in this important research animal.