CAROLINA AND GEORGIA GENETICS NETWORK CENTER

描述：（申请人描述）杜克大学，埃默里大学 和位于查佩尔山的北卡罗来纳州大学正在申请 成为癌症遗传学网络的成员。 我们将联合收割机 资源，建立合作临床实践，并增加受试者， 通用网络注册表。 我们网络中心的临床资源 非常大;加上我们的附属机构，我们的机构网络 每年治疗超过20，000例癌症病例。 我们的机构有 对基于人群的登记处的唯一访问，包括州癌症 参与遗传和分子流行病学研究的登记处、人群 研究和SEER登记。 我们从城市和农村社区汲取资源 我们的患者人群与种族特征 美国东南部 我们的卡罗莱纳和格鲁吉亚网络中心 在人类遗传学方面的广泛经验， 国家网络项目。 埃默里大学拥有全国公认的 医学遗传学计划和区域医学遗传学实验室， 专门的分子和基因检测。 北卡罗来纳州 有一个卓越的公共卫生学院，一个积极的外展计划， 促进医疗保健和几个有用的基于人口的癌症登记处。 杜克大学拥有庞大的临床业务和专业的基础科学系 基因组学、统计遗传学和分子生物学。 我们的中心已经 已经捕获了大量的患者， 癌症史。 我们正在进行遗传咨询的临床试验 战略，并有现场，低成本的乳腺癌检测设施 易感性 我们的调查人员已经开发出了案件确认方法 从我们的登记系统中捕获患者，以便进入研究。 我们 在基因检测方面得到了大量的机构支持， 临床癌症遗传服务和我们的教育计划。 人民 我们中心的专家将为网络规划的各个方面做出贡献， 准备修改我们的方法，使我们的中心与达成的共识保持一致， 网络规划活动。 在本申请中，我们建议 利用我们的专业知识和资源， 加强转介服务，并试行有选择地使用我们独特的 登记处。

DESCRIPTION: (Applicant's Description) Duke University, Emory University and the University of North Carolina at Chapel Hill (UNC) are applying to become members of the Cancer Genetics Network. We will combine our patient resources, establish cooperative clinical practices and accrue subjects to the common Network registry. The clinical resources of our Network Center are very large; together with our affiliates, our institutional networks care for more than 20,000 cancer cases each year. Our institutions have unique access to population-based registries, including state cancer registries, populations taking part in genetic and molecular epidemiology studies and SEER registries. We draw from both urban and rural communities and our patient population is directly comparable to the ethnic profile southeastern United States. Our Carolina and Georgia Network Center brings a breadth of experience in human genetics to the process of planning national Network projects. Emory University has a nationally recognized program of Medical Genetics and a regional Medical Genetics Laboratory for specialized molecular and genetic testing. The University of North Carolina has a remarkable School of Public Health, an active outreach program to foster health care and several useful population-based registries of cancer. Duke has vast clinical operations and a basic science faculty with expertise in genomics, statistical genetics and molecular biology. Our Center already has captured large populations of patients with well-documented family histories of cancer. We are conducting a clinic trial of genetic counseling strategies and have on-site, low cost testing facilities for breast cancer susceptibility. Our investigators have developed case ascertainment methods to capture patients from our registries for entry in research studies. We have received substantial institutional support for genetic testing, clinical cancer genetic services and our educational programs. The people in our Center will contribute to all aspects of Network planning and are ready to modify our approaches to align our Center with consensus reached by the Network planning activities. Within this application, we propose to take advantage of our expertise and resources to ascertain registrants by augmenting referral services and by piloting the selective use of our unique registries.