Prenatal set point for adult blood pressure

妊娠晚期胎羊将被治疗以产生全身和肺动脉高血压。一组会有高循环血管紧张素- ii水平。将有两个血压正常的对照组，一个是正常的，另一个是低血管紧张素- ii。这些动物将作为胎儿、新生儿和年轻的成年动物进行研究。循环测量包括动脉压、左右心房压和心输出量。我们还将制作血浆肾素活性/肾动脉压反应曲线和肾小球滤过率测量。分析测量将包括血浆肾素活性、循环血管紧张素- ii水平、儿茶酚胺、血浆蛋白和血红蛋白浓度、血气、渗透压和电解质。通过腺苷输注测定冠脉储备，在麻醉和不化学扩张情况下测定冠脉压力-血流关系。这些动物将被杀死，用于心脏和肾脏的结构研究。预计产前高血压将在以后的生活中产生持久的循环异常。

Late gestation fetal sheep will be treated to create systemic and pulmonary arterial hypertensions. One group will have high circulating angiotensin-II levels. There will be two normotensive control groups, one with normal and one with low angiotensin-II. The animals will be studied as fetuses, as newborns and as young adults. Circulatory measurements will include arterial pressures, right and left atrial pressures and cardiac outputs. We will also make plasma renin activity/renal ar6terial pressure response curves and measurements of glomerular filtration rates. Analytical measurements will include plasma renin activities, circulating angiotensin-II levels, catecholamines, plasma protein and blood hemoglobin concentrations, blood gases, osmolalities and electrolytes. Coronary pressure-flow relations will be determined under anesthesia with and without chemical dilation by means of adenosine infusions to determine coronary reserve. The animals will be killed for structural studies of heart and kidney. It is anticipated that prenatal hypertensions will produce lasting circulatory abnormalities later in life.