SELF-REGULATION DEPRESSIVE/ANXIOUS SYMPTOMS AND URIs

我们提出了一个由四项研究组成的研究项目，展示自我调节的情绪和生理后果如何影响月经功能障碍女性对上呼吸道疾病（uri）的易感性。该研究将测试一个模型，该模型假设自我调节的感知失败（作为高自我差异操作）通过负面情绪、月经功能障碍、应激激素（皮质醇）和免疫功能（自然杀伤细胞细胞毒性）的变化的中介影响增加对uri的易感性。研究1将通过受试者内启动操作，在有月经功能障碍的高、低自我差异女性和无月经功能障碍的女性中，检查自我调节认知的急性情绪、激素和免疫后果。研究2是对感冒和流感的发病率和严重程度作为自我调节功能的前瞻性调查，在6个月的学年期间进行，其中包括两个自然挑战（流感季节的开始和期末考试）。研究3将复制和扩展研究2的自我报告结果测量，通过测量高风险（高自我差异加月经功能障碍）与低风险（低自我差异无月经功能障碍）女性的流感病毒抗体，随机接受或不接受流感疫苗，然后随访两种自然挑战。研究4，再次通过自然主义挑战跟踪高风险和低风险妇女，将测试基于Pennebaker关于披露对健康影响的研究的简短干预。

We propose a program of research consisting of four studies demonstrating how the emotional and physiological consequences of self-regulation can influence susceptibility to upper respiratory illness (URIs) in women with menstrual dysfunction. The proposed research will test a model in which perceived failure in self-regulation (operationalized as high self-discrepancy) is hypothesized to increase susceptibility to URIs via the mediating influences of negative affect, menstrual dysfunction, and changes in stress hormones (cortisol) and immune function (natural killer cell cytotoxicity). Study 1 will examine the acute emotional, hormonal, and immunological consequences of self-regulatory cognition via a within-subject priming manipulation in high vs. low self-discrepant women with vs. without menstrual dysfunction. Study 2 is a prospective investigation of the incidence and severity of colds and flu as a function of self-regulation, conducted over a 6-month period of the academic year that includes two naturalistic challenges (the onset of the flu season and final exams). Study 3 will replicate and extend the self-report outcome measures of Study 2 by measuring antibodies to influenza virus in high-risk (high self-discrepancy plus menstrual dysfunction) vs. low-risk (low self-discrepancy without menstrual dysfunction) women randomized to receive or not receive flu vaccine and then followed through the two naturalistic challenges. Study 4, again following high-risk and low-risk women through naturalistic challenges, will test a brief intervention based on Pennebaker's studies of the health impact of disclosure.