CONTRIBUTIONS OF MEG TO THE SURGICAL MGMT OF EPILEPSY

描述：(逐字摘自申请人的摘要)目的 该项目旨在评估脑磁图(MEG)对 癫痫的外科治疗。具体地说，我们提出以下建议：第一， 为了估计脑磁图的相对精度，将其与表面和 侵袭性电生理学在确定要切除的致痫区域中的作用 在局灶性癫痫患者中。第二，探索是否有可能 脑磁图结合脑磁图数据识别致痫灶 来自世界反兴奋剂机构的其他标准非侵入性诊断程序和数据 在某些情况下，程序可能足够准确，从而不需要 侵入性电生理学。此外，我们建议研究是否 语言和记忆中不同半球参与的判断 从脑磁图得出的数据与常规从WADA程序得出的数据一致。 最后，除了回答上述主要问题外，我们还将 解决脑磁图是否影响侵入性手术计划的问题 电生理程序，我们将探索替代方法 通过考虑替代方案来提高其诊断准确性，目前还不是 脑磁图数据收集和分析的标准化模式。

DESCRIPTION: (Verbatim from the Applicant's Abstract) The purpose of this project is to evaluate the contributions of Magnetoencephalography (MEG) to the surgical management of epilepsy. Specifically, we propose the following: First, to estimate the relative accuracy of MEG, as compared to that of surface and invasive electrophysiology, in identifying epileptogenic zones to be resected in patients with focal epilepsy. Second, to explore the possibility that identification of epileptogenic zones based on MEG data combined with data from other standard non-invasive diagnostic procedures and data from the Wada procedure may, in some cases, be sufficiently accurate to obviate the need for invasive electrophysiology. In addition, we propose to examine whether judgements of differential hemispheric involvement in language and memory derived from MEG data concur with those routinely derived from Wada procedure. Finally, incidental to addressing the above main questions, we will also address the question as to whether MEG influences the planning of invasive electrophysiological procedures and we will explore alternative ways of improving its diagnostic accuracy by considering alternative, not yet standardized modes of MEG data collection and analysis.